ID   I3LZ17_ICTTR            Unreviewed;      1061 AA.
AC   I3LZ17;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=Ube3c {ECO:0000313|Ensembl:ENSSTOP00000001505.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001505.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000001505.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AGTP01108104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01108107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3LZ17; -.
DR   STRING; 43179.ENSSTOP00000001505; -.
DR   Ensembl; ENSSTOT00000001678.3; ENSSTOP00000001505.3; ENSSTOG00000001669.3.
DR   eggNOG; KOG0942; Eukaryota.
DR   GeneTree; ENSGT00940000156321; -.
DR   HOGENOM; CLU_028471_0_0_1; -.
DR   InParanoid; I3LZ17; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00015; IQ; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          722..1061
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          334..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1029
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1061 AA;  121296 MW;  628EC8EC8C09BD3D CRC64;
     EEKASLLHRT QEERRKREEE RRRLKNAIII QSFIRGYRDR KQQYSLQRSA FDRCAHSAQS
     GGTFSITNAP NLTLLVRQLL FFYKQSEDAK RLIWLYQNLI KHSSLFVKQL DGSERPTCLF
     QIKRLMSLCC RLLQSCNDDS LNVALPMRML EVFSSENTYL PVLQDASYVV SVIEQILHYM
     IHNGYYRSLY LLINSKLPSS IEYSDLSRVP IAKILLENVL KPLHFTYSSC PEGARQQVFS
     AFTEEFLAAP FTDQIFRFVI PALADVQTAF PYEPFLNALL LLESRCSKRS RGAPWLFYFV
     LTVGENYLGV LSEEGLLVYL HVLQTFLSQL PASPAGASSH DSTSDSEDES EEADKPASPE
     DGRVSAPYIT EECLKKLDTK QQTSALLNLV WRDSASEEVF TRMASICHTL MVQHRMMVPK
     VRLLYSLAFN ARFLRHLWVL ISSMTTRMIT GSMVPLLQVI SRGSPMSFED SGRIIPLFYL
     FSSLFSHSLI SIHDNEFFGD PIEVVGQRRS SMMPFTLEEL VALSRCLRDA CLGIIKLAYP
     ETKPEVREEY VTAFQSIGVT TSAEMQQCIQ MEQKRWIQLF KVITNLVKML KSRDTRRNFC
     PPNHWLSEQE DIKADKVTQL YVPASRHVWR FRRMGRIGPL QSTLEVGLES PPLTVSEERQ
     LAVLTELPFV VPFEERVKIF QRLIYADKQE VQGDGPFLDG INVTIRRNYI YEDAYDKLSP
     ENEPDLKKRI RVHLLNAHGL DEAGIDGGGI FREFLNELLK SGFNPNQGFF KTTNEGLLYP
     NPAAQMLVGD SFARHYYFLG RMLGKALYEN MLVELPFAGF FLSKLLGTSA DVDIHHLASL
     DPEVYRNLLF LKSYEEDVEE LGLNFTVVNN DLGEAQVVEL KLGGKDIPVT SANRIAYIHL
     VADYRLNKQI RPHCLAFRQG LANVVSLEWL RMFDQQEIQV LISGAQVPIS LEDLKSFTNY
     SGGYSADHPV IKIFWRVVEG FTDEEKRKLL KFVTSCSRPP LLGFKELYPA FCIHNGGSDL
     ERLPTASTCM NLLKLPEFYD ETLLRSKLLY AIECAAGFEL S
//