ID I3LZ63_ICTTR Unreviewed; 671 AA.
AC I3LZ63;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Uromodulin {ECO:0000256|ARBA:ARBA00015737};
GN Name=UMOD {ECO:0000313|Ensembl:ENSSTOP00000001577.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001577.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001577.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004303}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004303}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004539}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004539}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004609}. Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGTP01030896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3LZ63; -.
DR STRING; 43179.ENSSTOP00000001577; -.
DR Ensembl; ENSSTOT00000001767.3; ENSSTOP00000001577.3; ENSSTOG00000001765.3.
DR eggNOG; ENOG502QT6B; Eukaryota.
DR GeneTree; ENSGT00940000156742; -.
DR HOGENOM; CLU_028679_1_0_1; -.
DR InParanoid; I3LZ63; -.
DR TreeFam; TF330284; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019864; F:IgG binding; IEA:Ensembl.
DR GO; GO:0140367; P:antibacterial innate immune response; IEA:Ensembl.
DR GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0034620; P:cellular response to unfolded protein; IEA:Ensembl.
DR GO; GO:0061077; P:chaperone-mediated protein folding; IEA:Ensembl.
DR GO; GO:0046720; P:citric acid secretion; IEA:Ensembl.
DR GO; GO:0072044; P:collecting duct development; IEA:Ensembl.
DR GO; GO:0097709; P:connective tissue replacement; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
DR GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0030644; P:intracellular chloride ion homeostasis; IEA:Ensembl.
DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0072051; P:juxtaglomerular apparatus development; IEA:Ensembl.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0072218; P:metanephric ascending thin limb development; IEA:Ensembl.
DR GO; GO:0072221; P:metanephric distal convoluted tubule development; IEA:Ensembl.
DR GO; GO:0072233; P:metanephric thick ascending limb development; IEA:Ensembl.
DR GO; GO:0060073; P:micturition; IEA:Ensembl.
DR GO; GO:0033555; P:multicellular organismal response to stress; IEA:Ensembl.
DR GO; GO:1990266; P:neutrophil migration; IEA:Ensembl.
DR GO; GO:0002251; P:organ or tissue specific immune response; IEA:Ensembl.
DR GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
DR GO; GO:0072665; P:protein localization to vacuole; IEA:Ensembl.
DR GO; GO:0044861; P:protein transport into plasma membrane raft; IEA:Ensembl.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0051223; P:regulation of protein transport; IEA:Ensembl.
DR GO; GO:0035809; P:regulation of urine volume; IEA:Ensembl.
DR GO; GO:0070294; P:renal sodium ion absorption; IEA:Ensembl.
DR GO; GO:0097744; P:renal urate salt excretion; IEA:Ensembl.
DR GO; GO:0003091; P:renal water homeostasis; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0009414; P:response to water deprivation; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0008380; P:RNA splicing; IEA:Ensembl.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:Ensembl.
DR GO; GO:0015747; P:urate transport; IEA:Ensembl.
DR GO; GO:0071918; P:urea transmembrane transport; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF40; UROMODULIN; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..98
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 99..141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 142..183
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 368..623
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 73295 MW; 06D5499BE140E208 CRC64;
EGSQDFRHQG RNPQGPTHLC PRAAVPRTRT ERMGRLFSLT WWLMVTVATA WFIRAVATDS
SEARRCSECH SNATCTENGV VTTCSCQEGF TGDGLVCADL DECTIPGSHN CSTNSSCVNT
LGSYACVCAD GFRLLPGQGC VDVDECAEPE LSRCHALATC VNVEGSYVCM CPEGYGGDGW
HCECSPGSCG PGLDCVPEGD QLVCADPCQA HRILDEYWRS TEYGAGYTCD TDLSGWYRFV
GPGGMRLAET CVPILRCNTA APMWLNGTHP SSDEGIVNRT ACAHWSGHCC LWDTPIQVKA
CAGGYYVYNL TAAPECHLAY CTDPSSVEGT CEECSGDEDC ISDNGRWRCQ CRQDFNITDI
SYLERRLECG ANDIKVSLGK CQLKSLGFDK VFMYLRDSRC SGFREKGERD WMSVVTPAQD
GPCGTVLTRN ETHATYSNTL YLANEIIIRD VNIKINFACS YPLDMLVSLK TSLQPMVSAL
NISVGGTGEF TVRMALFQSS AYRQPYQGPS VALSTEAFLY VGTMLDGGDV SRFALLMTNC
YATPSGNATD PLKYFIIQDR CPHTADPTIQ VVENGESPQG RFAVQMFRFA GNYDLVYLHC
EVYLCDTANE KCKPSCSRAR FRSGGFVDSS RVLNLGPITR KGETAAPSSG LLLLKVWLPP
LVSVALTLTF H
//
