ID I3LZJ2_ICTTR Unreviewed; 103 AA.
AC I3LZJ2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Somatoliberin {ECO:0000256|ARBA:ARBA00040782};
DE AltName: Full=Growth hormone-releasing factor {ECO:0000256|ARBA:ARBA00042164};
DE AltName: Full=Growth hormone-releasing hormone {ECO:0000256|ARBA:ARBA00041953};
GN Name=GHRH {ECO:0000313|Ensembl:ENSSTOP00000001759.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001759.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001759.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC adenohypophyse to stimulate the secretion of growth hormone.
CC {ECO:0000256|ARBA:ARBA00037623}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; AGTP01059746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3LZJ2; -.
DR STRING; 43179.ENSSTOP00000001759; -.
DR Ensembl; ENSSTOT00000001976.3; ENSSTOP00000001759.3; ENSSTOG00000001984.3.
DR eggNOG; ENOG502S2N6; Eukaryota.
DR GeneTree; ENSGT00950000183154; -.
DR HOGENOM; CLU_174932_0_0_1; -.
DR InParanoid; I3LZJ2; -.
DR TreeFam; TF353187; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
DR GO; GO:0016608; F:growth hormone-releasing hormone activity; IEA:Ensembl.
DR GO; GO:0031770; F:growth hormone-releasing hormone receptor binding; IEA:Ensembl.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0021984; P:adenohypophysis development; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0030252; P:growth hormone secretion; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF6; SOMATOLIBERIN; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..103
FT /note="Somatoliberin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013379744"
FT DOMAIN 32..54
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 103 AA; 11914 MW; 09CE46302AC5F248 CRC64;
MPLWVFFFVI LTLSIGSHCS PSPSLPLRMR RYADAIFTNS YRKVLGQLSA RKLLQDIMSR
QQGERNQEQG ARVRLGRQVD STWEDQKQTA LESILVALLQ KHR
//
