ID I3LZK6_ICTTR Unreviewed; 1153 AA.
AC I3LZK6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSSTOP00000001777.3};
GN Name=SNX13 {ECO:0000313|Ensembl:ENSSTOP00000001777.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001777.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001777.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AGTP01054275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01054276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01054277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01054278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01054279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01054280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3LZK6; -.
DR STRING; 43179.ENSSTOP00000001777; -.
DR Ensembl; ENSSTOT00000001995.3; ENSSTOP00000001777.3; ENSSTOG00000001983.3.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_904761_0_0_1; -.
DR InParanoid; I3LZK6; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR CDD; cd06873; PX_SNX13; 1.
DR CDD; cd08719; RGS_SNX13; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037437; SNX13_PX.
DR InterPro; IPR037896; SNX13_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 293..480
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 569..692
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 755..876
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 131366 MW; 4CFE10828FE765E9 CRC64;
MRDGSFSTGN QSPGPRDAGD SQRHQSKSGL LPFSLLPRAG QLRRLGKDER TPRASIPDSL
RPRGRGFSPL AAIPSCPGHL ARGTPQPAAR GRPRARLHSS ARRRYGDGHE TPAAPAPANG
SARRGETRTS LFQDGGASVA SSRAGGKPAK PSKAAAWERI EGAVAAVGGG PSSFRYCYGC
CHAARLGRTS LPRGVIMLTE ASLSIWGWGS LGVVLFLVTF GPFVIFYLAF YILCFVGGGL
VVTLLFGKTN SEKYLEQCEH SFLPPTSTGV PKCLEEMKRE ARTIKIDRRL TGANIIDEPL
QQVIQFSLRD YVQYWYYTLS DDESFLLEIR QTLQNALIQF ATRSKEIDWQ PYFTTRIVDD
FGTHLRVFRK AQQRITEKDD QVKGTAEDLI DTFFEVEVEM EKEVCRDLVC TSPKDEEGFL
RDLCEVLLYL LLPPGDFQNK IMRYFVREIL ARGILLPLIN QLSDPDYINQ YVIWMIRDSN
CNYEAFMNII KLSDNIGELE AVRDKAAEEL QYLRSLDTAG DDINTIKNQI NSLLFVKKVC
DSRIQRLQSG KEINTVKLAA NFGKLCTVPL DSILVDNVAL QFFMDYMQQT GGQAHLFFWM
TVEGYRVTAQ QQLEVLLSRQ RDGKHQTNQT KGLLRAAAVG IYEQYLSEKA SPRVTVDDYL
VAKLADTLNH EDPTPEIFDD IQRKVYELML RDERFYPSFR QNALYVRMLA ELDMLKDPSF
RGSDDGDGES FNGSPTGSIN LSLDDLSSVS SDDSVQLHAY ISDTGVCNDH GKTYALYAIT
VHRRNLNSEE MWKTYRRYSD FHDFHMRITE QFENLSSILK LPGKKTFNNM DRDFLEKRKK
DLNAYLQLLL TPEMMKASPA LAHCVYDFLE NKAYSKGKGD FARKMDTFVN PLRNSMRNVS
NAVKSLPDSL AEGMTKMSDN MGKMSERLGQ DIKQSFFKVP PLITKTDSDP EHCRVSAQLD
DNVDDNIPLR VMLLLMDEVF DLKERNQWLR RNIKNLLQQL IRATYGDTIN RKIVDHVDWM
TSPEQVADSV KRFRDAFWPN GILAESVPCR DKAIRMRTRI AGKTKLFAIM PDELKHIIGA
ETTRKGILRV FEMFQHNQLN RRMVYVFLEG FLETLFPQYK FRELFNKLHS RSKQMQKYKQ
KLQTTQAPSL QKR
//
