ID I3M1K0_ICTTR Unreviewed; 842 AA.
AC I3M1K0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=G protein-coupled receptor associated sorting protein 2 {ECO:0000313|Ensembl:ENSSTOP00000002712.2};
GN Name=GPRASP2 {ECO:0000313|Ensembl:ENSSTOP00000002712.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000002712.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000002712.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GPRASP family.
CC {ECO:0000256|ARBA:ARBA00011013}.
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DR EMBL; AGTP01109654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013220833.1; XM_013365379.1.
DR AlphaFoldDB; I3M1K0; -.
DR STRING; 43179.ENSSTOP00000002712; -.
DR Ensembl; ENSSTOT00000003039.3; ENSSTOP00000002712.2; ENSSTOG00000003047.3.
DR eggNOG; ENOG502S6CE; Eukaryota.
DR GeneTree; ENSGT00940000162726; -.
DR HOGENOM; CLU_017437_0_0_1; -.
DR InParanoid; I3M1K0; -.
DR OMA; WPREEAN; -.
DR TreeFam; TF335652; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR043374; GASP1-3.
DR PANTHER; PTHR46414; PROTEIN BHLHB9-RELATED; 1.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 599..816
FT /note="Armadillo repeat-containing"
FT /evidence="ECO:0000259|Pfam:PF04826"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 94068 MW; DC6EE9F62EB4FCA5 CRC64;
MTGAEIETGA QAKSEKKAGE EVVSGAEREN EVPLVVRPKV RAQAQVTTGA RPKTETKSAS
GARPKTEAQK VAGARPKTEA QTMAGARPKT ETQAMAGARP KTDARAVGGA RPKSEAKTVS
GARPKDDAQA WAQTEFGTEA MSQAEGASQT NAVTWPLVNT DSGSVTKSKG LPVDRELVSL
DAETFPGNQG QAGIQPWFGP GEETSMGSWC YPRPRAREEA SNESGFWSAD ETSTVSSFWA
GEEASIRSWP REEANTRSRH RAKHQTNPRS KSTSKQEPYI DSWSGSEDES GNPFCFWAGE
NTNNLFRPRA REEANVRSKL RTKREDYFES ESEDEFYKES WFLPGEEANN RFRRRDKEEP
NNILKSRAQK DDKNIDRAKQ EPRFEEDVII GSWFWAEKEA SLEAGASAIC ESEPGAEEGA
IGGSLFWAEE KSSLGAVARE ETRPESEEEA IFGSWFWDRD EACFDLNPSP VYKANCRYRD
PAEDELNASS RPQTWEEVTV EFKPGPCHGV GFPSTSPFRI PEGSSEMNEA KSKNVELGPE
GEEQESSLQS DRAEPEFPFQ YDPSYRSVRE IREHLRARES AEPENWSCSC IQCELKIGSG
EFEELLLLMD KIRDPFIHEI SKIAMGMRSA SQFTRDFIRD SGVVSLIETL LNYPSSRVRT
SFLENMIHMA PPYPNLNMIE TFICQVCEET LAHGVDSLEQ MTGIRMLRHL TMTTDYHTLI
ANYMSGFLSL LTTGNARTKF HVLKMLLNLS ENPMVAKKLF SAKALSIFVG LFNIEETNDN
IQIVIKMFQN ISNIIKSGAL SLIDDDFSLD PLMSAFHEFE ELAKDLQVQI DNQNDPEVGQ
HS
//
