ID I3M1L4_ICTTR Unreviewed; 777 AA.
AC I3M1L4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Tax1 binding protein 1 {ECO:0000313|Ensembl:ENSSTOP00000002731.3};
GN Name=TAX1BP1 {ECO:0000313|Ensembl:ENSSTOP00000002731.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000002731.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000002731.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|ARBA:ARBA00004419}. Preautophagosomal structure
CC {ECO:0000256|ARBA:ARBA00004329}.
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DR EMBL; AGTP01012157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01012158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01012159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01012160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01012161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M1L4; -.
DR STRING; 43179.ENSSTOP00000002731; -.
DR Ensembl; ENSSTOT00000003059.3; ENSSTOP00000002731.3; ENSSTOG00000003056.3.
DR eggNOG; ENOG502QQ1D; Eukaryota.
DR GeneTree; ENSGT00950000183025; -.
DR HOGENOM; CLU_021315_2_0_1; -.
DR InParanoid; I3M1L4; -.
DR TreeFam; TF329501; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039532; P:negative regulation of cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:1905161; P:protein localization to phagocytic vesicle; IEA:Ensembl.
DR CDD; cd21969; Zn-C2H2_TAX1BP1_rpt1; 1.
DR CDD; cd21970; Zn-C2H2_TAX1BP1_rpt2; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR012852; CALCOCO1-like.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31915:SF8; TAX1-BINDING PROTEIN 1; 1.
DR Pfam; PF07888; CALCOCO1; 1.
DR Pfam; PF17751; SKICH; 1.
DR Pfam; PF18112; Zn-C2H2_12; 2.
DR PROSITE; PS51905; ZF_UBZ1; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 715..741
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT DOMAIN 742..768
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT REGION 635..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 349..469
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 538..590
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 777 AA; 89758 MW; 050C79E2E13C9C61 CRC64;
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA
RDYYTFLWSP MPEHYVEGST VNCVLKFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELIQLIAV LEKETVQLRE
QVGRMERELN NEKERCEHLQ AEQKGLIEVS QSLKMENEEF KKRYGDATSK ALQLEEDIVS
VTHKAIEKET ELDSLKDKLR KVQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLVSE
VQTLKNLDGN KESMITHFKE EIGRLQLCLA EKENLQRAFL LTTSNKEDSF SLKEQLRKAE
EQVQATRQEV VFLAKELSDA VNVRDKTMAD LHTARLENEK VKKQLADALA ELKLNAVKKD
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNVFTKKV
GNQQKVNDAS INTDPATSVS AVDVKLPLSS ADEKTKCSKY ADELAKMELK WKEQMKIVEN
VKLELAEVED NYKLQLAEKD KEISGLTSHL ENLSREKELK RNLENQTEKK MEVHSSQQNS
QCLNTCSEQN GHVHVLPNVQ PVLQYGNPYA TQETRDGADG AFYPDEIQRP PVRVPSWEDN
VVCSQPSRNL SRPDGLEDPE DSKEDENVPT VSDPPSQHLR GHGTGFCFDS SFDVHKKCPL
CELMFPPNYD QSKFEEHVES HWKVCPMCSE QFPPDYDQQG FERHVQTHFD QHVLNFD
//
