ID I3M287_ICTTR Unreviewed; 2277 AA.
AC I3M287;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Notch receptor 3 {ECO:0000313|Ensembl:ENSSTOP00000003054.3};
GN Name=NOTCH3 {ECO:0000313|Ensembl:ENSSTOP00000003054.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003054.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000003054.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGTP01071561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01071562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000003054; -.
DR Ensembl; ENSSTOT00000003412.3; ENSSTOP00000003054.3; ENSSTOG00000003378.3.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160234; -.
DR HOGENOM; CLU_000576_0_0_1; -.
DR InParanoid; I3M287; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0072104; P:glomerular capillary formation; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0014016; P:neuroblast differentiation; IEA:Ensembl.
DR GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 23.
DR CDD; cd21704; JMTM_Notch3; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 31.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022331; Notch_3.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044:SF496; METALLOENDOPEPTIDASE; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00008; EGF; 19.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 6.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01986; NOTCH3.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 32.
DR SMART; SM00179; EGF_CA; 29.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 17.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 16.
DR PROSITE; PS00022; EGF_1; 29.
DR PROSITE; PS01186; EGF_2; 24.
DR PROSITE; PS50026; EGF_3; 32.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 12..50
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 51..91
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 92..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 131..168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 170..207
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 209..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 257..295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 334..372
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..443
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 445..481
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 483..519
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 521..556
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 558..594
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 612..648
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 650..685
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 689..725
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..763
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 765..802
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 804..840
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 842..877
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 879..915
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 917..953
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 955..989
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1001..1037
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1039..1075
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1077..1113
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1115..1158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1160..1199
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1201..1242
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1244..1280
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1290..1328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1342..1382
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1383..1413
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1422..1460
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1793..1825
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1860..1892
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1893..1925
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1926..1958
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1979..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2140..2167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2213..2240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2248..2268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 398
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 448
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 462
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 40..49
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 81..90
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 119..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 197..206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 285..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 343..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 416..431
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 449..460
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 454..469
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 471..480
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 509..518
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 525..535
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 638..647
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 654..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 675..684
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 715..724
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 753..762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 792..801
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 830..839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 846..856
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 867..876
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 905..914
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 943..952
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 979..988
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1027..1036
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1065..1074
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1103..1112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1148..1157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1189..1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1232..1241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1270..1279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1299..1316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1318..1327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2277 AA; 239112 MW; CD36E2C8D62BF48C CRC64;
PLLLLLAGPG AAAPPCLDRS PCANGGRCTQ LPSREAACLC PPGWVGERCQ LEDPCHSGPC
AGRGVCQSSV VAGTARFSCR CPRGFRGPDC SLPDPCLSSP CAHGARCSVG SDGRFICSCP
PGYQGRSCRS DIDECRVGGP CRHGGTCLNT PGSFHCQCPN GYTGPLCENP TVPCAPSPCR
NGGTCRQNGD LTYDCACLPG FEGQNCEVNV DDCPGHRCLN GGTCVDGVNT YNCQCPPEPW
VAILVHLCAT GQFCTEDVDE CQLQPNACHN GGTCFNTLGG HSCVCVNGWT GESCSQNIDD
CATAVCFHGA TCHDRVASFY CACPMGKTGL LCHLDDACVS NPCHEDAICD TNPVNGRAIC
TCPPGFTGGA CDQDVDECSI GERAPFEKET RKRGVVGSQL VMPTLFVPHS TGANPCEHLG
RCVNTQGSFL CQCGRGYTGP RCETDVNECL SGPCRNQATC LDRIGQFTCI CMAGFSGSTC
QLDVDECAST PCRNGAKCVD QPDGYECRCA EGFEGTLCEH NVDDCSPDPC HHGRCVDGIA
SFSCACAPGY TGTRCESQVD ECRSQPCRHG GKCLDLVDKY LCRCPPGTTG TVHLEGHIQF
GNGVNCPLCN VEINECASNP CGEGGSCVDG ENGFSCLCPP GSLPPLCLPP THPCAHEPCS
HGICHDAPGG FRCVCEPGWS GPRCSQSLAR DACESQPCGA GGTCISDGMG FHCTCPPGVQ
GRQCELLSPC TPNPCEHGGR CESAPGQLTV CSCPPGWQGP RCQQDVDECA GPSPCGAHGS
CTNLAGSFSC TCHGGYTGPS CDQDINDCDP NPCLNGGSCQ DSVGSFSCSC LPGFAGPRCA
HDVDECLSNP CGPGTCTDHV ASFTCTCPPG YGGFHCEKDL PNCSPSSCFN GGTCVDGVNS
FSCLCRPGYL GAHCQYEADP CLSRPCLHGG VCSATHPGFH CACREGFTGS QCQTLVDWCS
HEPCQNGGRC VQNGAYCLCP PGWSGRLCDI RSLPCREAAA QIGVRLEQLC QAGGQCVDQD
SSHYCVCPEG RTGSYCEHEV DPCLAQPCQH GGTCRGYMGG YMCECPAGYS GDNCEDDVDE
CASQPCQHGG SCIDLVDRYL CSCPPGTLGV LCEINEDDCG PGPPLDSGPR CLNNGTCVDL
VGGFHCNCPP GYTGLHCEAD INECRPGACH AAHTRDCLQD PGGHFRCLCH AGFTGPRCQT
VLAPCESQPC QHGGQCRPSP GPGGGLTFTC HCVQPFWGPR CEQVARSCRE LQCPVGVPCQ
QTARGPRCAC PPGLSGPSCR GSRGSSQGAA NATCAALPCL HGGSCRAAPL APFFRCLCVP
GWDGPRCETP AAAPEITEEP RCPRAACQAK RGDKRCDREC NSPGCGWDGG DCSLSVGDPW
RQCEALQCWR LFNNSRCDPA CSSPACLYDN FDCHTGGRER TCNPVYEKYC ADHFADGRCD
QGCNTEECGW DGLDCASEVP ALLARGVLVL TVLLPPEELL RSSADFLQRL SAILRTSLRF
RLDARGQAMV FPYHRPSPGS ELRTRRELAP EVIGSVVMLE IDNRLCLQSP ENDHCFPDAQ
SAADYLGALS AVERLDFPYP LRDVRGEPME LPEPSVPLLP LLAAGAVFLL VILVLGVMVA
RRKREHSTLW FPEGFALHKD VAAGHKGRRE PVGQDALGMK NMAKSESLMG EVATDWMDTE
CPEAKRLKVE EPGMGAEEPV DCRQWTQHHL VAADIRVAPA MALTPPQGDA DADGMDVNVR
GPDGFTPLML ASFCGGALEP MPTEEDEADD TSASIISDLI CQGAQLGART DRTGETALHL
AARYARADAA KRLLDAGADT NAQDHSGRTP LHTAVTADAQ GVFQILIRNR STDLDARMAD
GSTALILAAR LAVEGMVEEL IASHADVNAV DELGKSALHW AAAVNNVEAT LALLKNGANK
DMQDSKEETP LFLAAREGSF EAAKLLLDHF ANREITDHLD RLPRDVAQER LHQDIVRLLD
QPSGPRSPPG PHGLGPLLCP PGAFLPGLKA AQSGAKKSRR PPGKAGLGPQ GARGRGKKLT
LACPGPLAES SVTLSPVDSL DSPRPFGGPP ASPGGFPLEG PYAAATATAV SLAQLGGTGR
AGPLGRQPPG GCVLSLGLLN PVAVPLDWAR LPPPAPPGPS FLLPLAPGPQ MLNPGTPVSP
QERPPPYLAA PGHGEEYPAA GAHSSPPKAR FLRVPSEHPY LTPSPESPEH WASPSPPSLS
DWSDSTPSPA TASGATATAA GTLPAQPHPL TVPSSLAQAQ TQLGPQPEVT PKRQVLA
//
