ID I3M2U4_ICTTR Unreviewed; 598 AA.
AC I3M2U4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN Name=POLA2 {ECO:0000313|Ensembl:ENSSTOP00000003333.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003333.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000003333.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; AGTP01072414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01072415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005333503.1; XM_005333446.2.
DR AlphaFoldDB; I3M2U4; -.
DR STRING; 43179.ENSSTOP00000003333; -.
DR Ensembl; ENSSTOT00000003721.3; ENSSTOP00000003333.3; ENSSTOG00000003707.3.
DR GeneID; 101971245; -.
DR CTD; 23649; -.
DR eggNOG; KOG1625; Eukaryota.
DR GeneTree; ENSGT00390000016784; -.
DR HOGENOM; CLU_014923_3_1_1; -.
DR InParanoid; I3M2U4; -.
DR OrthoDB; 49016at2759; -.
DR TreeFam; TF314249; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005658; C:alpha DNA polymerase:primase complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR Gene3D; 3.60.21.60; -; 2.
DR Gene3D; 1.10.8.530; DNA polymerase alpha-primase, subunit B, N-terminal domain; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR043034; DNA_pol_alpha_B_N_sf.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 25..239
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 342..549
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 107..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 66277 MW; 56AF6F740462AEDD CRC64;
MPVSTQQLAE ELQIFGLDCE DAQIEKLAEL CVLYGQNEEG MVGELIAFCT STKKAHLTPE
VLSTFEHEIL SKRLSKTWHS SSKDSGHAGA RDIISIQELI EVEEEEETLL NSYTTPSKGP
QKRALTMPET PLTKRSVSAR SPHQLLSPSS FSPSATPSKK YNSRNNRGEV VTTFGSAQGV
SWSGRGGVGS ISLKVLGYPE PLTGSYKSMF QKLPDIREVL TCKIEELGSE LKEHYRIEAF
TPLLVPAQEP VTLLGQIGCD SNGKLNSKSV ILEGDREHSS GAQIPVDLTE LKEYSLFPGQ
VVIMEGINTT GRKLIATKLY EGVPLPFYQP TEEDGDFEQT MVMVACGPYT TSDSITYEPL
LDLITVINRD RPDVCVLFGP FLDAKHEQVE NCLLTSPFED VFRQCLRTII EGTRSSGSHL
VFVPSLRDVH HEPVYPQPPF SYSDLSREDK KRVQFVSEPC SLSVNGVIFG LTSTDLLFHM
GAEEISSSSG TSDRLSRILK HILTQRSYYP LYPPQEDMAI DYENFYAYAQ LLVTPDVLIV
PSELRYFVKD ILGCVCVNPG RLTKGQVGGT FGRLYLRRLL AAGETRQSPC IAAQVVRI
//
