ID   I3M346_ICTTR            Unreviewed;       699 AA.
AC   I3M346;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=EEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSSTOP00000003452.2};
GN   Name=METTL13 {ECO:0000313|Ensembl:ENSSTOP00000003452.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003452.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000003452.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AGTP01015013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005319865.1; XM_005319808.2.
DR   AlphaFoldDB; I3M346; -.
DR   STRING; 43179.ENSSTOP00000003452; -.
DR   Ensembl; ENSSTOT00000003850.3; ENSSTOP00000003452.2; ENSSTOG00000003852.3.
DR   GeneID; 101967919; -.
DR   CTD; 51603; -.
DR   eggNOG; KOG2352; Eukaryota.
DR   GeneTree; ENSGT00510000047399; -.
DR   HOGENOM; CLU_010025_1_0_1; -.
DR   InParanoid; I3M346; -.
DR   OMA; REIEWLF; -.
DR   OrthoDB; 179741at2759; -.
DR   TreeFam; TF105906; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF037959; MFS_SpdSyn; 1.
DR   PANTHER; PTHR12176:SF78; EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR   Pfam; PF13847; Methyltransf_31; 1.
DR   Pfam; PF01564; Spermine_synth; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          47..162
FT                   /note="Methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF13847"
FT   REGION          433..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   699 AA;  78564 MW;  0238DC9AAC9CBDC8 CRC64;
     MNLLPKSSKE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE RVLVIGCGNS
     ELSEQLYDVG YQDIVNIDIS EAVIKQMKER NASRRPQMSF LKMDMTQMEF PDAAFQVVLD
     KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
     VRVHQVASSQ DQVLEAESRF SLPVFAFVMT KFRPVPGSAL QIFELCAQEQ GKPVRLESAE
     RLAEAVRERQ QYAWLCSQLR RKAGLGSVSL DLCSGDTGEP RYTLHVVDSP AVKPSRDNHF
     AIFIIPQGRE TEWLFGMEEG RKQLAASAGF RRLVTVALHR GQQYDGMDSV QAELSSRVME
     LAPAGMPPQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDRRY FRRLIFLSNR
     NVVQSEARLL KDVSHRAQKK RKKDKKKQRP ADTPEDLPPA PGQSVDKSYL CCEHHKAMIA
     GLALLRNPEL LLETPLALLV VGLGGGSLPL FVHDHFPKSC IDAVEIDPSM LEVATRWFGF
     AQSERMKVHI ADGLDYITSL AGGEARPLYD VIMFDVDSKD PTLGMSCPPP AFVDQPFLQK
     VKSILTHEGV FILNLVCRDL ALKDSVLAGL KAVFPVLYVR RIEGEVNEIL FCQLHPGQKL
     ATSELLEMAQ ALERTLRRPG RGWDDTYVLS DMLKTVKIV
//