ID   I3M377_ICTTR            Unreviewed;      1195 AA.
AC   I3M377;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Cingulin {ECO:0000256|ARBA:ARBA00044075};
GN   Name=Cgn {ECO:0000313|Ensembl:ENSSTOP00000003488.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003488.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000003488.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probably plays a role in the formation and regulation of the
CC       tight junction (TJ) paracellular permeability barrier.
CC       {ECO:0000256|ARBA:ARBA00043864}.
CC   -!- SIMILARITY: Belongs to the cingulin family.
CC       {ECO:0000256|ARBA:ARBA00038467}.
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DR   EMBL; AGTP01066266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01066267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3M377; -.
DR   STRING; 43179.ENSSTOP00000003488; -.
DR   Ensembl; ENSSTOT00000003892.3; ENSSTOP00000003488.3; ENSSTOG00000003867.3.
DR   eggNOG; ENOG502R9EI; Eukaryota.
DR   GeneTree; ENSGT00940000162698; -.
DR   HOGENOM; CLU_002036_0_0_1; -.
DR   InParanoid; I3M377; -.
DR   TreeFam; TF332247; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349:SF4; CINGULIN; 1.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          814..1145
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          72..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1152..1174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          354..416
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        72..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1152..1170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1195 AA;  136793 MW;  23F3B80F0774C979 CRC64;
     AMAEPRGPVD HGVQIRFITE PEGGAEMDTI RRGVRRPTKD ARANTYGVAV RVQGIAGQPF
     VVLNSGEKGS DSFGVQIKGS DNQGAPGTLS SDSELPENPY SQVKGFPASS QGSTSDEEPG
     SYWNGRLPRS QSQASLAGPI PMDSSNRSNS LLELAPKETS PDSTIDTAPL SSVDSLINKF
     DSQVGGQTRG RTGRRTRTLP HEQRKRSQSL DSRLPQDPLE EQERQSPDHW TPSAKYDNHV
     GSLKQPSQSP SPVRGLSHPH PAQDWVIQSF EEPQERARDP TMLQFKSTPD LLRDQQETAP
     PGSVDHVKAT IYGILKEGSS ESEASVRRKV SLVLEQMEPL VMASPDSTKT IAGQSEVTRK
     VEELQKKLEE EVKKRQKLEP SRVRLERQLE EKAEECDRLQ DLLERKKGDA QQSTKELQNM
     KLLLDQGDRL RHGLETQVME LQNKLKQGQG SEPAKEVLLK ELLETRELLE EVLEGKQRVE
     EQLRLREREL TALKGALKEE VASRDQEMEQ VRQQYQRDTE QLRRSMQDAT QDHAVLEAER
     QKMSALVRGL QRELEETSEE TEHWQTMFQK NKEELRATKQ ELLQLRMEKE EMEEELGEKV
     EVLQREVEHA RASTRDNLQL EELKELRWAQ DELKELRAQR QNQEAAGRHR DQELEKQLAV
     LRVEADRVRE LEQQNAQLQK TLQQLKQDCE EASKAKVAAE AETAVLGQRR AAVETTLRET
     QEENDEFRRR ILGLEQQLKE AHGLAEGGEA VEARLRDRVQ RLEAEKLRLQ EALNEAQEEE
     GSLVAAKRAL EVRLEEAQRG LARLGQEQQA LSRALEEEGK QREVLRRSKA ELEEQKRLLD
     RTVDRLNKEL EQIGDDSKQA LKQLQAQLED YKEKARREVA DAQRQAKDWA SEAEKTSGGL
     SRLQDEIQRL RQALQASQAE RDTALLDKEL LVQRLQGLEQ EAENKKRSQD DRTRQLKNLE
     EKVSRLEAEL DEEKNTVELL SDRVNRGRDQ VDQLRAELMQ ERSARQDLEC DKISLERQNK
     DLKTRLTNLE GFQKPSASFS QLESQNQMLQ ERLQAEEREK TVLQSTNRKL ERRVKELSIQ
     IDDERQHVND QKDQLSLRVK ALKRQVDEAE EEIERLDGLR KKAQRELEEQ HEVNEQLQAR
     IKSLEKEAWR KTSRSAAEST LKHEGLSSDE EFDGVYDPSS IASLLTESNL QTSSC
//