ID I3M4I5_ICTTR Unreviewed; 752 AA.
AC I3M4I5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=GIT ArfGAP 2 {ECO:0000313|Ensembl:ENSSTOP00000004111.3};
GN Name=GIT2 {ECO:0000313|Ensembl:ENSSTOP00000004111.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004111.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004111.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01105172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01105173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01105174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M4I5; -.
DR STRING; 43179.ENSSTOP00000004111; -.
DR Ensembl; ENSSTOT00000004581.3; ENSSTOP00000004111.3; ENSSTOG00000004553.3.
DR GeneTree; ENSGT00940000156383; -.
DR HOGENOM; CLU_009739_0_0_1; -.
DR InParanoid; I3M4I5; -.
DR TreeFam; TF317762; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..112
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 154..186
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 368..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 425..466
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 396..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 83693 MW; FE8C1FA9B71CF0E8 CRC64;
VCITCYPSWA SVNRGTFICD ECCSVHRSLG RHISQVRHLK HTPWPPTLLQ MVETLYNNGA
NSIWEHSLLD PASITSGRRK ANPQDKVHPN KAEFIRAKYQ MLAFVHRLPC RDDDSVTAKD
LSKQLHSSVR TGNLETCLRL LSLGAQANFF HPEKGNTPLH VASKAGQILQ AELLAVYGAD
PGTHDSSGKT PVDYARQGGH HELAERLVEI QYELTDRLAF YLCGRKPDHK NGQHFIIPQM
ADSSLDLSEL AKAAKKKLQS LSNHLFEELA MDVYDEVDRR ETDAVWLATQ NHSTLVTETT
VVPFLPVNPE YSSTRNQGRQ KLARFNAHEF ATLVIDILSD AKRRQQGSPL SGSKDNVELI
LKTINNQHSI ESQDNDQPDY DSVASDEDTD LETTASKANR QKSLDSDLSD GPVTVQEFME
VKNALVASEA KIQQLMKVNN NLSDELRIMQ KKLQTLQSEN SNLRKQATTN VYHVQTGSEY
PDTSNHSSLK RRPSARGSRP MSMYETGSGQ KPYLPMGEAN HPEESRTRLQ PFPAHIGRSA
LVTSSSSLPS FPSTLSWSRD ESTRRASRLE KQNSTPESDY DNTPNDTEPD DTGVLGVGSQ
GPGRQRSMVW PGECSMPDPP ESHTAPSPTL PSTEDVIRKT EQITKNIQEL LRAAQENKHD
SYIPCSERIH VAVTEMAALF PKKPKSDMVR TSLRLLTSSA YRLQSECKKA LPGDSGSPTD
VQLVTQQVIQ CAYDIAKAAK QLVTITTKEN NN
//
