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Database: UniProt
Entry: I3M4N4_ICTTR
LinkDB: I3M4N4_ICTTR
Original site: I3M4N4_ICTTR 
ID   I3M4N4_ICTTR            Unreviewed;      2316 AA.
AC   I3M4N4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   23-MAY-2018, entry version 43.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=Cacna1b {ECO:0000313|Ensembl:ENSSTOP00000004189};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004189, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000004189}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000004189}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AGTP01090665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000004189; -.
DR   Ensembl; ENSSTOT00000004667; ENSSTOP00000004189; ENSSTOG00000004575.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3M4N4; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    105    122       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    143    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    176    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    231    253       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    308    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    341    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    557    575       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    618    640       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    696    718       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1132   1150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1170   1190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1202   1220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1263   1285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1375   1400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1456   1474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1486   1509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1521   1545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1566   1595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1664   1687       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1703   1738       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      371    391       {ECO:0000256|SAM:Coils}.
FT   COILED      721    747       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2316 AA;  259118 MW;  7CD123E8B1F36201 CRC64;
     MVRFGDELGG RYGGAGSGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN
     PIPVKQNCFT VNRSLFVFSE DNVVRKYAKL LHCTATGLCR CGASWPYMIL ATIIANCIVL
     ALEQHLPDGD KTPMSERLDD TEPYFIGIFC FEAGIKIIAL GFAFHKGSYL RNGWNVMDFV
     VVLTGILATA GTDFDLRTLR AVRVLRPLKL VSGIPSLQVV LKSIMKAMVP LLQIGLLLFF
     AILMFAIIGL EFYMGKFHKA CFPNSSDADP VGDFPCGKEA PARLCEGDTE CREYWPGPNF
     GITNFDNILF AILTVFQCIT MEGWTDILYN TNDAAGNTWN WLYFIPLIII GSFFMLNLVL
     GVLSGEFAKE RERVENRRAF LKLRRQQQIE RELNGYLEWI FKAEEVMLAE EDKNAEEKSP
     LDAVLKRAAT KKSRHDLIHA EEGEDRLADL CAVGSPFARA SLKSGKTESS SYFRRKEKMF
     RFFIRRMVKA QSFYWVVLCV VALNTLCVAM VHYNQPQRLT TALYFAEFVF LGLFLTEMSL
     KMYGLGPRSY FRSSFNCFDF GVIVGSIFEV VWAAIKPGTS FGISVLRALR LLRIFKVTKY
     WNSLRNLVVS LLNSMKSIIS LLFLLFLFIV VFALLGMQLF GGQFNFKDET PTTNFDTFPA
     AILTVFQILT GEDWNAVMYH GIESQGGVSK GMFSSFYFIV LTLFGNYTLL NVFLAIAVDN
     LANAQELTKD EEEMEEAANQ KLALQKAKEV AEVSPMSAAN ISIAARQQNS AKARSVWEQR
     ASQLRLQNLR ASCEALYSEM DPEERMRYAT TRHLRPDMKT HLDRPLVVEP PGRDGPRGPM
     GGKARPEGTE VTEGVDPPRR HHRHRDRDKV QAVVPAVGEQ DRAESVDPGA REERARPHRS
     RSKDAAGGGR RHHRRGSPEE AAEREPRRHR AHRHGPEQGK EGVAPTAKSE RRLRHRGPRA
     GSREAESGEE PMRRHRARHK VPSVQEPTEK EATEKEACVS TSSGEPHCGL EASGVMGIAP
     VHVLPSTCLQ KVEEQPEDAD NQRNVTRMGI ESSDPSSTLH VPVTLAGPPG ETTVAPSGNL
     DLESQAEGKK EAEADDMLRS GPRPIVPYSS MFCLSPTNLL RRFCHYIVTM RYFEMVILVV
     IALSSIALAA EDPVRTDSSR NNALKYMDYI FTGVFTFEMV MKMIDLGLLL HPGAYFRDLW
     NILDFIVVSG ALVAFAFSGS KGKDINTIKS LRVLRVLRPL KTIKRLPKLK AVFDCVVNSL
     KNVLNILIVY MLFMFIFAVI AVQLFKGKFF YCTDESKELE RDCRGQYLDY EKEEVEAQPR
     QWKKYDFHYD NVLWALLTLF TVSTGEGWPM VLKHSVDATY EEQGPSPGFR MELSIFYVVY
     FVVFPFFFVN IFVALIIITF QEQGDKVMSE CSLEKNERAC IDFAISAKPL TRYMPQNKQS
     FQYKTWTFVV SPPFEYFIMA MIALNTVVLM MKFYDAPYEY ELMLKCLNMV FTSMFSLECV
     LKIIAFGVLN YFRDAWNVFD FVTVLGSITD ILVTEIANNF INLSFLRLFR AARLVKLLRQ
     GYTIRILLWT FVQSFKALPY VCLLIAMLFF IYAIIGMQVF GNIALDDDTS INRHNNFRTF
     LQALMLLFRS ATGEAWHEIM LSCLSNRACD PDANASECGS DFAYFYFVSF IFLCSFLMLN
     LFVAVIMDNF EYLTRDSSIL GPHHLDEFIR VWAEYDPAAC GRISYNDMFE MLKHMSPPLG
     LGKKCPARVA YKRLVRMNMP ISSEDMTVHF TSTLMALIRT ALEIKLAPAG AKQHQCDAEL
     RKEISSVWAN LPQKTLDLLV PPHKPDEMTV GKVYAALMIF DFYKQNKTTR DQIHQAPGGL
     SQMGPVSLFH PLKATLEQTQ PAVLRGARVF LRQKSSTSLS NGGAIQTQES GIKESVSWGT
     QRTQDALYEA RAPLERGHSA EIPVGQPGTL AADVQMQNMA LRGPDGEPQP GLESQGRAAS
     MPRLAAETQP APDASPMKRS ISTLAQRSHG GHLCNTTLDR PPPSQAPHHH HHRCHRRRDK
     KQRSLEKGSS QHADTDGAPN SAAGPSLPPG EGPTGCRRER ERKQERGRSQ ERRQPSSSSS
     EKQRFYSCDR FGGREHPQPK PSLSSHPTSP TAGEPGPPPQ GSGSINGSPL LSTSGASTPG
     RGGRRQLPQT PLTPRPSITY KTANSSPVHF AGAQSGLPAF SPGRLSRGLS EHNALLQRDP
     LSQPLAPGSR ISSDPYLGQR MDSEASAHTL PEDTLTFEEA VATNSGRSSR TSYVSSLTSQ
     SHPLRRVPNG YHCTLGLGTG SRARHSYHHP DQDHWC
//
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