ID I3M4T9_ICTTR Unreviewed; 568 AA.
AC I3M4T9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Zinc finger protein {ECO:0000256|PIRNR:PIRNR037162};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037162};
GN Name=PRDM5 {ECO:0000313|Ensembl:ENSSTOP00000004269.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004269.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004269.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01089145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01089146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01089147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01089148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01089149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01089150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01089151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M4T9; -.
DR STRING; 43179.ENSSTOP00000004269; -.
DR Ensembl; ENSSTOT00000004755.3; ENSSTOP00000004269.3; ENSSTOG00000004741.3.
DR GeneTree; ENSGT00940000158340; -.
DR HOGENOM; CLU_002678_75_0_1; -.
DR InParanoid; I3M4T9; -.
DR TreeFam; TF106478; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1903053; P:regulation of extracellular matrix organization; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR017125; Znf_PRDM5-like.
DR PANTHER; PTHR24399:SF23; C2H2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR Pfam; PF12874; zf-met; 1.
DR PIRSF; PIRSF037162; PRDM; 3.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PIRNR:PIRNR037162};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|PIRNR:PIRNR037162};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PIRNR:PIRNR037162};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 1..93
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 136..164
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 168..190
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 200..230
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 233..255
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 258..285
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 286..313
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 314..341
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 342..369
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 370..398
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 399..426
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 427..454
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 455..482
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 483..510
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 511..538
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 540..563
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 568 AA; 65838 MW; 11337F3C1FF533C6 CRC64;
GEKFGPFAGE KRMPEDLDEN MDCRLMWEVR GSKGEVLYIL DATNPRHSNW LRFVHEAPSQ
EQKNLAAIQE GENIFYLAVE DIETDTELLI GYLDSDLEAE EEEQQIVTVI REAAAEDSKG
QSSAGRKDPL GYTEDFACPQ CESSFPSAEI LAEHLQMLHQ RPTEEKEFKC KICGKKFPVQ
QALQRHSEQH QEMCRGDARF VCRANSCGKR LKSKDALKRH QENVHAGDPK KKLVCSVCSK
KCSSASSLQE HRKVHEIFDC QECMKKFVSA NQLKRHLITH SERRPYHCEI CNKSFKRLDQ
VGAHKVIHSE DKPYKCKLCG KGFAHRNVYK NHKKTHSQER PFQCEECKAL FRTPFSLQRH
LLIHTSERTF KCHHCEATFK RKDTLNVHVQ VVHERHKKYS CELCNKAFVT PSVLRSHKKT
HTGEKEKVCP YCGQKFASSG TLRVHIRSHT GERPYQCPYC DKGFSKNDGL KMHIRTHTRE
KPYKCSECSK AFSQKRGLEE HKRTHTGEKP FQCDVCDLAF SLKKMLIRHK MTHNPHRPLA
ECQFCHKKFT RNDYLKVHRD HVHGVADS
//
