ID I3M5W7_ICTTR Unreviewed; 521 AA.
AC I3M5W7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Sorting nexin-1 {ECO:0000256|ARBA:ARBA00020434};
GN Name=SNX1 {ECO:0000313|Ensembl:ENSSTOP00000004780.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004780.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004780.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004546}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004546}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004546}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AGTP01003171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01003172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005316733.1; XM_005316676.1.
DR AlphaFoldDB; I3M5W7; -.
DR Ensembl; ENSSTOT00000005332.3; ENSSTOP00000004780.3; ENSSTOG00000005324.3.
DR GeneID; 101960328; -.
DR CTD; 6642; -.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000155889; -.
DR HOGENOM; CLU_022783_2_0_1; -.
DR OrthoDB; 1891044at2759; -.
DR TreeFam; TF313698; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd07665; BAR_SNX1; 1.
DR CDD; cd07281; PX_SNX1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR034901; PX_SNX1.
DR InterPro; IPR028660; SNX1_BAR.
DR InterPro; IPR005329; Sorting_nexin_N.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF129; SORTING NEXIN-1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF03700; Sorting_nexin; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 142..271
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 58919 MW; EA5D45E96908E5D2 CRC64;
MASGGGGCSA SERLPPPFPG LDAESEGTAG GSEPEGGDSD TEGEDIFTGA AAANKPQSPK
RLSILPINNG SKENGIEEEQ DQEPQDLFAD ATVELSLDST QNNQKTVPAK TLISLPPQEA
TNSSKPQPSY EELEEEEQED HFDLTVGITD PEKIGDGMNA YVAYKVTTQT SLPMFRSKQF
AVKRRFSDFL GLYEKLSEKH SQNGFIVPPP PEKSLIGMTK VKVGKEDSSS AEFLEKRRAA
LERYLQRVVN HPTMLQDPDV REFLEKEELP RAVGTQTLSG AGLLKMFNKA TDAVSKMTIK
MNESDIWFEE KLQEVECEEQ RLRKLHAVVE TLVNHRKELA LHTAQFAKSL AMLGSSEDNT
ALSRALSQLA EVEEKIEQLH QEQANNDFFL LAELLSDYIR LLAIVRAAFD QRMKTWQRWQ
DAQAMLQKKR EAEARLLWAN KPDKLQQAKD EITEWESRVT QYERDFERIS TVVRKEVIRF
EKEKSKDFKN HVIKYLETLL YSQQQLAKYW EAFLPEAKAI S
//
