ID I3M5X9_ICTTR Unreviewed; 995 AA.
AC I3M5X9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSSTOP00000004802.3};
GN Name=GARNL3 {ECO:0000313|Ensembl:ENSSTOP00000004802.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004802.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004802.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01020049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01020058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M5X9; -.
DR Ensembl; ENSSTOT00000005360.3; ENSSTOP00000004802.3; ENSSTOG00000005340.3.
DR GeneTree; ENSGT00940000159362; -.
DR HOGENOM; CLU_764971_0_0_1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 169..385
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 467..778
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 787..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 110818 MW; AC6835B59205215C CRC64;
MKSSVSEDLG CRRGDFSRKH YGSVELLISS DADGAIQRAG RFRVENGSSD ENATALPGTW
RRTDVHLENP EYHTRWYFKY FLGQVHQNYI GNDAEKSPFF LSVTLSDQNN QRVPQYRAIL
WRKTGTQKIC LPYSPTKTLS VKSILSAMNL DKFEKGPREI FLPEIQKDLL VLEEQEGSVN
FKFGVLFAKD GQLTDDEMFS NEIGSEAFQK FLNLLGDTIT LKGWTGYRGG LDTKNDTTGI
HSVYTVYQGH EIMFHVSTML PYSKENKQQV ERKRHIGNDI VTIVFQEGEE SSAAFKPSMI
RSHFTHIFAL VRYDQQNDNY RLKIFSEESV PLFGPPLPSP PVFTDHQEFR DFLLVKLING
EKATLETPTF AQKRRRTLDM LIRSLHQDLM PDLHKNMLNR RSFSDVLPES PKSARKKEEA
RQAEFVRIGQ ALKLKSIVRG DAPSSLATSG ICKKEPWEPQ CFCSNFPHEA VCADPWGQAL
LVSTDAGVLL VDDDLPSVPV FDRTLPVKQM HVLETLDLLV LRADKGKDAR LFVFRLSAVQ
KGLEGRQTGR GRSDCRENKL EKTKGCHLYA INTHHSKELR IVVAIRNKLL LITRKHNKPS
AVTGVSLLSP LSESPVEEFQ YIREICLSDS PAVMTLVDGP TEESDNLICV AYRHQFDVVN
ESTGEAFRLH HVEASRVNFV AAIDVYEDGE AGLLLCYNYS CIYKKVCPFN GGSFLVQPSA
SDFQFCWNQA PYAIVCAFPY LLAFTPDSME IRLVVNGNLV HTAVVPQLQL VASRSDIYFT
AAATVPEVSS GGSSKGASAH SSPQTPPGRD TAVFPSSLGE GEIQSKNLYR IPLRNLVGRS
IERPLKSPLV SKVITPPTSI SLGIAAIPVT HSLSLSRMEI KEIASRTRRE LLGLSDESGP
RAEGAPRAKS KPRKRLEENQ GGPKPGTVRS TSSDRIPSGS LESPSTSEVN PEACYHSTSS
DQDPVAEREG SPVSVWGSSP FQLTASSDED IIDLK
//
