ID   I3M649_ICTTR            Unreviewed;       419 AA.
AC   I3M649;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Vesicle amine transport 1 like {ECO:0000313|Ensembl:ENSSTOP00000004896.3};
GN   Name=VAT1L {ECO:0000313|Ensembl:ENSSTOP00000004896.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004896.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000004896.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00010371}.
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DR   EMBL; AGTP01010257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01010258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01010259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01010260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01010261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005318509.1; XM_005318452.1.
DR   AlphaFoldDB; I3M649; -.
DR   STRING; 43179.ENSSTOP00000004896; -.
DR   Ensembl; ENSSTOT00000005473.3; ENSSTOP00000004896.3; ENSSTOG00000005476.3.
DR   GeneID; 101969636; -.
DR   CTD; 57687; -.
DR   eggNOG; KOG1198; Eukaryota.
DR   GeneTree; ENSGT00940000159184; -.
DR   HOGENOM; CLU_026673_3_1_1; -.
DR   InParanoid; I3M649; -.
DR   OrthoDB; 6736at2759; -.
DR   TreeFam; TF314255; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08275; MDR3; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   PANTHER; PTHR44054; SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE; 1.
DR   PANTHER; PTHR44054:SF2; SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          51..378
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  45964 MW;  8E87D96E7ECD3E3B CRC64;
     MAKEGVEKAE ETEQMIEKEP SKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF GGLNKLRLSR
     KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL VPGFECSGIV EALGDSVKGY
     EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP DDMSFSEAAA FPMNFVTAYM MLFEVANLRE
     GMSVLVHSAG GGVGQAVAQL CSTVPNVTVF GTASTFKHEA IKESVTHLFD RNADYVQEVK
     RISAEGVDIV LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK
     VNPIKLYEEN KVIAGFSLLH LLFKQGRAGL VRGVVDRLIG LYNQKKIKPV VDSLWALEEV
     KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE EEEDHEGDSE NKERMPFIQ
//