ID I3M6X0_ICTTR Unreviewed; 62 AA.
AC I3M6X0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Metallothionein {ECO:0000256|RuleBase:RU000621};
GN Name=MT4 {ECO:0000313|Ensembl:ENSSTOP00000005279.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005279.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000005279.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC that bind various heavy metals. {ECO:0000256|RuleBase:RU000621}.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.
CC {ECO:0000256|ARBA:ARBA00007283, ECO:0000256|RuleBase:RU000621}.
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DR EMBL; AGTP01009392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01009393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005318255.1; XM_005318198.2.
DR AlphaFoldDB; I3M6X0; -.
DR STRING; 43179.ENSSTOP00000005279; -.
DR Ensembl; ENSSTOT00000005900.3; ENSSTOP00000005279.2; ENSSTOG00000005917.3.
DR GeneID; 101974610; -.
DR CTD; 84560; -.
DR eggNOG; KOG4738; Eukaryota.
DR GeneTree; ENSGT00950000182967; -.
DR HOGENOM; CLU_171204_2_0_1; -.
DR InParanoid; I3M6X0; -.
DR OMA; DKCGCCP; -.
DR TreeFam; TF336054; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:Ensembl.
DR Gene3D; 4.10.10.10; Metallothionein Isoform II; 1.
DR InterPro; IPR017854; Metalthion_dom_sf.
DR InterPro; IPR023587; Metalthion_dom_sf_vert.
DR InterPro; IPR000006; Metalthion_vert.
DR InterPro; IPR018064; Metalthion_vert_metal_BS.
DR PANTHER; PTHR23299; METALLOTHIONEIN; 1.
DR PANTHER; PTHR23299:SF12; METALLOTHIONEIN-4; 1.
DR Pfam; PF00131; Metallothio; 1.
DR PRINTS; PR00860; MTVERTEBRATE.
DR SUPFAM; SSF57868; Metallothionein; 1.
DR PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000621};
KW Metal-thiolate cluster {ECO:0000256|ARBA:ARBA00022851,
KW ECO:0000256|RuleBase:RU000621};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
SQ SEQUENCE 62 AA; 6312 MW; 848AC0114785333A CRC64;
MDPGDCTCMS GGMCICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI CKGSSDKCNC
CA
//
