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Database: UniProt
Entry: I3M7G8_ICTTR
LinkDB: I3M7G8_ICTTR
Original site: I3M7G8_ICTTR 
ID   I3M7G8_ICTTR            Unreviewed;      1063 AA.
AC   I3M7G8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=SLIT-ROBO Rho GTPase activating protein 2 {ECO:0000313|Ensembl:ENSSTOP00000005559.3};
GN   Name=Srgap2 {ECO:0000313|Ensembl:ENSSTOP00000005559.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005559.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000005559.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AGTP01058204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01058205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01058206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01058207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01058208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01058209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01058210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3M7G8; -.
DR   Ensembl; ENSSTOT00000006217.3; ENSSTOP00000005559.3; ENSSTOG00000006198.3.
DR   GeneTree; ENSGT00950000182824; -.
DR   HOGENOM; CLU_048287_0_0_1; -.
DR   TreeFam; TF315892; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd07682; F-BAR_srGAP2; 1.
DR   CDD; cd04383; RhoGAP_srGAP; 1.
DR   CDD; cd11955; SH3_srGAP1-3; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035648; srGAP1/2/3_SH3.
DR   PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR14166:SF6; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          22..325
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          488..671
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          720..779
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          181..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          689..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          829..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          975..1004
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1021..1063
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          363..397
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        181..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..876
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..923
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1037..1063
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1063 AA;  119880 MW;  BAC76BB54A8A9F35 CRC64;
     MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE
     MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY
     LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK
     LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT
     ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDQCC DLGYHASLNR ALRTFLSAEL
     NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG DMASQLCAQQ
     PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD IVTVEDFDVS DCFQYSNSME
     SVKSTVSETF MSKPSIAKRR ANQQETEQFY FTKMKEYLEG RNLITKLQAK HDLLQKTLGE
     SECGNSPWRL DSSQAIPLVV ESCIRFISRH GLQHEGIFRV SGSQVEVNDI KNAFERGEDP
     LAGDQNDHDM DSIAGVLKLY FRGLEHPLFP KDIFHDLMAC VTMDNLQERA LHIRKVLLVL
     PKTTLIIMRY LFAFLNHLSQ FSEENMMDPY NLAICFGPSL MSVPEGHDQV SCQAHVNELI
     KTIIIQHENI FPNPKELEGP VYSRGGSMED YCDSPHGETT SAEDSTQDVT AEHHTSDDEC
     EPIEAIAKFD YVGRTARELS FKKGASLLLY QRASDDWWEG RHNGIDGLIP HQYIVVQDTE
     DGVVERSSPK SEIEVISEPP EEKVTARAGA SCPSGGHVAD IYLANINKQR KRPESGSIRK
     TFRSDSHGLS SSLTDSSSPG VGASCRPSSQ PIMSQSLPKE GPDKCSISGH GSLNSISRHS
     SLKNRLDSPQ IRKTATAGRS KSFNNHRPMD PEVIAQDIEA TMNSALNELR ELERQSSVKH
     TPDVVLDTLE PLKTSPVVAP TSEPSSPLHT QLLKDPEPAF QRSASTAGDI ACAFRPVKSV
     KMAAPVKPPA TRPKPTVFPK TNATSPGVNS SASPQSTDKS CTV
//
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