ID I3M7R8_ICTTR Unreviewed; 649 AA.
AC I3M7R8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Leucine-rich repeat and WD repeat-containing protein 1 {ECO:0000256|ARBA:ARBA00015536};
DE AltName: Full=Origin recognition complex-associated protein {ECO:0000256|ARBA:ARBA00033046};
GN Name=LRWD1 {ECO:0000313|Ensembl:ENSSTOP00000005680.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005680.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000005680.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the LRWD1 family.
CC {ECO:0000256|ARBA:ARBA00007545}.
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DR EMBL; AGTP01053289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005328559.1; XM_005328502.2.
DR AlphaFoldDB; I3M7R8; -.
DR STRING; 43179.ENSSTOP00000005680; -.
DR Ensembl; ENSSTOT00000006352.3; ENSSTOP00000005680.3; ENSSTOG00000006339.3.
DR GeneID; 101963050; -.
DR CTD; 222229; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154248; -.
DR HOGENOM; CLU_022994_0_0_1; -.
DR InParanoid; I3M7R8; -.
DR OrthoDB; 5398890at2759; -.
DR TreeFam; TF329554; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005721; C:pericentric heterochromatin; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0008327; F:methyl-CpG binding; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0006325; P:chromatin organization; IEA:Ensembl.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0071169; P:establishment of protein localization to chromatin; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR24370:SF10; LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24370; OPTICIN; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 390..424
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 234..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 71361 MW; 57BA04CC3D9D31BE CRC64;
MGPLTARLLM QRGRPKSDRL GKIRSLDLSR LNLLSEHLDP KLLSRLKQLQ ELDLSYNLLE
ALPPNLGLPH LRILRCANNQ LGDVTALSQF PQLEELSLEG NPFLTVNDNL KVSFLLPKLR
KVNGKDASST CAQMENLNRE LTNRVTAHWE KFMAALGPGK ETKKAQADFV KSAVRDVCYG
PDSLREFTQW RVRMISEELV ASGGTQVHEA DVPKRPQETT ATYKPRARLV SLKRPDDVPL
NLPSTKRACN SPSVQMEDDP SGPDSSQPAL QLEPLHFLQC HSRNNSPQDL KTQLWSCAFE
PAWEEGHSGA TSQTVATCGG EAVCVIDCQT GIVLHKYKAP GEEFFSVAWT ALTVVTQAGH
KKRWNVLAAA GLRGLVRLLH VRAGFCCGVI RAHKKAIATL CFSPIHETHL FTASYDKRII
LWDIGVPNPD YEFQASQLLT LDSTSIPLRL CPVAPCPDAY LLAGCEGGCC CWDVRLDQPQ
KRRVCEVEFI FSAGSQAPGR RVDGLAFVNE DVVASKGSGL GTICLWSWSQ TWAGRGSQSP
VAVVVLAQLQ WSSTELAYFS LSACPEKGVV LCGDEEGSVW IYDVGHILKQ PPPQLAAPQA
PVQILKWPQP LALGQPVTKT MVNTVVANSA LTYLTALTDS NIIAVWRRC
//
