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Database: UniProt
Entry: I3M8D6_ICTTR
LinkDB: I3M8D6_ICTTR
Original site: I3M8D6_ICTTR 
ID   I3M8D6_ICTTR            Unreviewed;       765 AA.
AC   I3M8D6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   31-JUL-2019, entry version 45.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=STAT5B {ECO:0000313|Ensembl:ENSSTOP00000005990};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005990, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000005990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000005990}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; AGTP01023484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01023485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000006697; ENSSTOP00000005990; ENSSTOG00000006691.
DR   eggNOG; KOG3667; Eukaryota.
DR   eggNOG; ENOG410XPN8; LUCA.
DR   GeneTree; ENSGT00950000182688; -.
DR   InParanoid; I3M8D6; -.
DR   TreeFam; TF318648; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
DR   GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   CDD; cd10420; SH2_STAT5b; 1.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR035858; STAT5a/5b.
DR   InterPro; IPR035886; STAT5b_SH2.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      568    665       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      127    147       {ECO:0000256|SAM:Coils}.
FT   COILED      194    214       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   765 AA;  87568 MW;  B1C94E9A8FFFAC7D CRC64;
     MVEHLPSVFW KEIILVEERL DVDSIDLDNP QENIKATQLL EGLVQELQKK AEHQVGEDGF
     LLKIKLGHYA TQLQNTYDRC PMELVRCIRH ILYNEQRLVR EANNGSSPAG SLADAMSQKH
     LQINQTFEEL RLVTQDTENE LKKLQQTQEY FIIQYQESLR LQAQFAQLAQ LNPQERLSRE
     TALQQKQVSL EAWLQREAQT LQQYRVELAE KHQKTLQLLR KQQTIILDDE LIQWKRRQQL
     AGNGGPPEGS LDVLQSWCEK LAEIIWQNRQ QIRRAEHLCQ QLPIPGPVEE MLAEVNATIT
     DIISALVTST FIIEKQPPQV LKTQTKFAAT VRLLVGGKLN VHMNPPQVKA TIISEQQAKS
     LLKNENTRND YSGEILNNCC VMEYHQATGT LSAHFRNMSL KRIKRSDRRG AESVTEEKFT
     ILFESQFSVG GNELVFQVKT LSLPVVVIVH GSQDNNATAT VLWDNAFAEP GRVPFAVPDK
     VLWPQLCEAL NMKFKAEVQS NRGLTKENLV FLAQKLFNSS SAHLEDYNSM SVSWSQFNRE
     NLPGRNYTFW QWFDGVMEVL KKHLKPHWND GAILGFVNKQ QAHDLLINKP DGTFLLRFSD
     SEIGGITIAW KFDSQERMFW NLMPFTTRDF SIRSLADRLG DLNYLIYVFP DRPKDEVYSK
     YYTPVPCEPA TAKAVDGYVK PQIKQVVPEF VNANTDAGAS TTYMDQAPSP SVCPQAHYNM
     YPQNPDAVLD TDGDFDLEDT MDVARRVEEL LGRPMDSQWI PHAQS
//
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