ID I3M8U0_ICTTR Unreviewed; 519 AA.
AC I3M8U0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Serine incorporator 4 {ECO:0000313|Ensembl:ENSSTOP00000006206.3};
GN Name=SERINC4 {ECO:0000313|Ensembl:ENSSTOP00000006206.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000006206.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000006206.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
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DR EMBL; AGTP01002358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013214662.1; XM_013359208.1.
DR AlphaFoldDB; I3M8U0; -.
DR STRING; 43179.ENSSTOP00000006206; -.
DR Ensembl; ENSSTOT00000006943.3; ENSSTOP00000006206.3; ENSSTOG00000006939.3.
DR GeneID; 101960424; -.
DR CTD; 619189; -.
DR eggNOG; KOG2592; Eukaryota.
DR GeneTree; ENSGT01030000234623; -.
DR HOGENOM; CLU_029574_5_2_1; -.
DR InParanoid; I3M8U0; -.
DR OrthoDB; 53161at2759; -.
DR TreeFam; TF312881; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF5; SERINE INCORPORATOR 4; 1.
DR Pfam; PF03348; Serinc; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 394..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 57025 MW; B9C49B8592B8E882 CRC64;
MVGTKSTIGP STSVGLAQQH NGVIVKTPFC QMSCCGTVPC TSSCHSRRPS LTESTCSRLF
YILLHVGASA VCCLLLSRTV VERVWGEAHG IQMPSGLCSH LFGHSACPVV SGSGAVYRIC
AGTATFHLLQ AVLLVHLHSP TSPRAQLHNS FWFLKVLFLL GLCAAAFCIP DEHLLPAWHY
IGICGGFTFI LLQLVLITAF AHSWNKNWQT GAAQDCSWFL AVLLATLGFY SMAGLGAMLL
FQHYTHPAGC LLNKMLLSMH LCFCGLLSFL SIAPCIRLRQ PRSGLLQASI ISCYIMYLTF
SALSSRPPER VILQGQNLTL CLPGLNKMEP PISDTSLAAL SAGIMYACVL FACNEASYLA
EVFGPLWIIK VYSYEFQKPS LCFCCPETVE PGDGQTDGAT RPTDQETPQT PPPQAQHLSY
SYSAFHFVFF LASLYVMVTL TNWFSYEGAE LEKTFTKGSW ATFWVKVASC WACILLYLGL
LLAPLCWTPT QDPKPRLTFR KHYHMASVLP DNSLQSKSF
//
