ID I3M974_ICTTR Unreviewed; 801 AA.
AC I3M974;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Zinc finger protein X-linked {ECO:0000313|Ensembl:ENSSTOP00000006397.3};
GN Name=ZFX {ECO:0000313|Ensembl:ENSSTOP00000006397.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000006397.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000006397.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01079192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01079193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01079194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013218092.1; XM_013362638.1.
DR AlphaFoldDB; I3M974; -.
DR STRING; 43179.ENSSTOP00000006397; -.
DR Ensembl; ENSSTOT00000007158.3; ENSSTOP00000006397.3; ENSSTOG00000007158.3.
DR GeneID; 101967029; -.
DR CTD; 7543; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158684; -.
DR HOGENOM; CLU_021097_0_0_1; -.
DR InParanoid; I3M974; -.
DR OrthoDB; 4630845at2759; -.
DR TreeFam; TF335557; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0048599; P:oocyte development; IEA:Ensembl.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0060746; P:parental behavior; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393:SF34; FEZ FAMILY ZINC FINGER PROTEIN ERM; 1.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR Pfam; PF04704; Zfx_Zfy_act; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 421..451
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 452..474
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 484..511
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 515..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 544..571
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 572..600
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 601..628
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 629..657
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 658..685
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 686..714
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 715..742
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 743..771
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 772..799
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 801 AA; 90219 MW; D8A93E9FE1E3CA9F CRC64;
MDEDGLELQP QEPNSFFDAT GADATHMDGD QIVVEVQETV FVSDVVDSDI TVHNFVPDDP
DSVVIQDVIE DVVIEDVQCP DIMEEADVSE TVIIPEQVLD SDVTEEVSLA HCTVPDDVLA
SDITSASMSM PEHVLTSESI HVSDVGHVEH VVHDSVVEAE IVTDPLTTDV VSEEVLVADC
ASEAVIDANG IPVDQQDDDK SNCEDYLMIS LDDAGKIEHD GSSGMTMDAE SEIDPCKVDG
TCPEVIKVYI FKADPGEDDL GGTVDIVESE PENDHGVELL DQNSSIRVPR EKMVYMTVND
SQQEDEDLNV AEIADEVYME VIVGEEDAAA AAAAAAAVHE QQMDDNEIKT FMPIAWAAAY
GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKRRRP DSRQYQTAII IGPDGHPLTV
YPCMICGKKF KSRGFLKRHM KNHPEHLAKK KYRCTDCDYT TNKKISLHNH LESHKLTSKA
EKAIECDECG KHFSHAGALF THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK
NFPHICVECG KGFRHPSELK KHMRIHTGEK PYQCQYCEYR SADSSNLKTH VKTKHSKEMP
FKCDICLLTF SDTKEVQQHA LIHQESKTHQ CLHCDHKSSN SSDLKRHIIS VHTKDYPHKC
DMCDKGFHRP SELKKHVAAH KGKKMHQCRH CDFKIADPFV LSRHILSVHT KDLPFRCKRC
RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY STTDASGFKR HVISIHTKDY PHRCEYCKKG
FRRPSEKNQH IMRHHKEVGL P
//
