ID I3M9F4_ICTTR Unreviewed; 351 AA.
AC I3M9F4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Translation initiation factor eIF2B subunit beta {ECO:0000256|ARBA:ARBA00044122};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit beta {ECO:0000256|ARBA:ARBA00044228};
GN Name=EIF2B2 {ECO:0000313|Ensembl:ENSSTOP00000006511.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000006511.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000006511.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a component of the translation initiation factor 2B
CC (eIF2B) complex, which catalyzes the exchange of GDP for GTP on
CC eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine
CC nucleotide exchange factor activity is repressed when bound to eIF2
CC complex phosphorylated on the alpha subunit, thereby limiting the
CC amount of methionyl-initiator methionine tRNA available to the ribosome
CC and consequently global translation is repressed.
CC {ECO:0000256|ARBA:ARBA00043898}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; AGTP01020521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005321299.1; XM_005321242.1.
DR AlphaFoldDB; I3M9F4; -.
DR STRING; 43179.ENSSTOP00000006511; -.
DR Ensembl; ENSSTOT00000007287.3; ENSSTOP00000006511.2; ENSSTOG00000007283.3.
DR GeneID; 101957794; -.
DR CTD; 8892; -.
DR eggNOG; KOG1465; Eukaryota.
DR GeneTree; ENSGT00550000074908; -.
DR HOGENOM; CLU_016218_4_3_1; -.
DR InParanoid; I3M9F4; -.
DR OMA; SHSCAVA; -.
DR OrthoDB; 169494at2759; -.
DR TreeFam; TF101506; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:Ensembl.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR45859; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR PANTHER; PTHR45859:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
SQ SEQUENCE 351 AA; 39010 MW; 8620DFCA98341CA2 CRC64;
MPGAAAKGSE LSERIESFVE TLKRGGGQRS SEHMARETLG LLRRIITDHR WSNAGELMEL
IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLSE
DFSVHYDQLQ SNIIEAINEL LVELEGTTEN IAAQALEHIH SNEVIMTIGF SRTVEAFLKE
AARKRKFHVI VAECAPFCQG HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL
ANGALRAVAG THTLALAAKH HFTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV L
//
