ID I3MA18_ICTTR Unreviewed; 297 AA.
AC I3MA18;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|ARBA:ARBA00020823, ECO:0000256|RuleBase:RU367091};
GN Name=EMC2 {ECO:0000313|Ensembl:ENSSTOP00000006788.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000006788.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000006788.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC (EMC) that enables the energy-independent insertion into endoplasmic
CC reticulum membranes of newly synthesized membrane proteins.
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SIMILARITY: Belongs to the EMC2 family. {ECO:0000256|ARBA:ARBA00010361,
CC ECO:0000256|RuleBase:RU367091}.
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DR EMBL; AGTP01001854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005316304.1; XM_005316247.1.
DR AlphaFoldDB; I3MA18; -.
DR STRING; 43179.ENSSTOP00000006788; -.
DR Ensembl; ENSSTOT00000007593.3; ENSSTOP00000006788.3; ENSSTOG00000007594.3.
DR GeneID; 101956696; -.
DR CTD; 9694; -.
DR eggNOG; KOG3060; Eukaryota.
DR GeneTree; ENSGT00390000011922; -.
DR HOGENOM; CLU_052388_1_0_1; -.
DR InParanoid; I3MA18; -.
DR OrthoDB; 312673at2759; -.
DR TreeFam; TF312997; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0032977; F:membrane insertase activity; IEA:Ensembl.
DR GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; IEA:Ensembl.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039856; EMC2-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW Membrane {ECO:0000256|RuleBase:RU367091};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 87..120
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 155..188
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 297 AA; 34850 MW; D3EF1C47A3A17EE5 CRC64;
MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD DIWIIYEQVM
IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAVQLY DRILQEDPTN
TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE
LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA
SNPKASAKMK KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
//
