ID   I3MAK2_ICTTR            Unreviewed;       509 AA.
AC   I3MAK2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Nucleus accumbens associated 1 {ECO:0000313|Ensembl:ENSSTOP00000007032.2};
GN   Name=NACC1 {ECO:0000313|Ensembl:ENSSTOP00000007032.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000007032.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000007032.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AGTP01088448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005336286.1; XM_005336229.2.
DR   AlphaFoldDB; I3MAK2; -.
DR   STRING; 43179.ENSSTOP00000007032; -.
DR   Ensembl; ENSSTOT00000007859.3; ENSSTOP00000007032.2; ENSSTOG00000007865.3.
DR   GeneID; 101965475; -.
DR   CTD; 112939; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000159327; -.
DR   HOGENOM; CLU_029038_1_0_1; -.
DR   InParanoid; I3MAK2; -.
DR   OMA; DMMSMEH; -.
DR   OrthoDB; 5342883at2759; -.
DR   TreeFam; TF331184; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   CDD; cd18290; BTB_POZ_BTBD14B_NAC1; 1.
DR   Gene3D; 1.10.10.2590; BEN domain; 1.
DR   InterPro; IPR018379; BEN_domain.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46105; AGAP004733-PA; 1.
DR   PANTHER; PTHR46105:SF3; NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF10523; BEN; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM01025; BEN; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS51457; BEN; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   4: Predicted;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          30..94
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   DOMAIN          356..453
FT                   /note="BEN"
FT                   /evidence="ECO:0000259|PROSITE:PS51457"
FT   REGION          131..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  55659 MW;  E73FECAC23693A2C CRC64;
     MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN
     SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL IYTAGFLQIQ EIMEKGTEFF
     LKVSSPSCDS QGLHAEEAPS SEPQSPVAQT SGWPACSTPL PLVSRVKTEQ QESDSVQCTP
     VAKRLWDSSQ KEAGGSSSGN GSRKMAKFST PDLATNRTPQ PAPVVAAAVA AGGVMSGPST
     SERTSPGTSS AYTSDSPGSY HNEEDEEEDA GEEGADEQYR QICNMYTMYS MMNVGQTAEK
     VEALPEQVAP ESRSRIRVRQ DLASLPAELI NQIGNRCHPK LYDEGDPSEK LELVTGTNVY
     ITRAQLMNCH VSAGTRHKVL LRRLLASFFD RNTLANSCGT GIRSSTNDPR RKPLDSRVLH
     AVKYYCQNFA PNFKESEMNA IAADMCTNAR RVVRKSWMPK AKPMLAEGDA YTTFISDTGK
     MEPDMMSMEH GFETASHDGE AGPSAEVLQ
//