ID I3MBG6_ICTTR Unreviewed; 544 AA.
AC I3MBG6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Extracellular matrix protein 1 {ECO:0000313|Ensembl:ENSSTOP00000007479.3};
GN Name=ECM1 {ECO:0000313|Ensembl:ENSSTOP00000007479.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000007479.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000007479.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01066189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013216683.1; XM_013361229.1.
DR AlphaFoldDB; I3MBG6; -.
DR STRING; 43179.ENSSTOP00000007479; -.
DR Ensembl; ENSSTOT00000008345.3; ENSSTOP00000007479.3; ENSSTOG00000008340.3.
DR GeneID; 101973831; -.
DR CTD; 1893; -.
DR eggNOG; ENOG502RY3T; Eukaryota.
DR GeneTree; ENSGT00390000006215; -.
DR HOGENOM; CLU_038587_0_0_1; -.
DR InParanoid; I3MBG6; -.
DR OrthoDB; 4577436at2759; -.
DR TreeFam; TF330786; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
DR GO; GO:0003416; P:endochondral bone growth; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0030502; P:negative regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0002828; P:regulation of type 2 immune response; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.246.10; -; 3.
DR InterPro; IPR008605; ECM1.
DR InterPro; IPR020858; Serum_albumin-like.
DR PANTHER; PTHR16776; EXTRACELLULAR MATRIX PROTEIN 1; 1.
DR PANTHER; PTHR16776:SF3; EXTRACELLULAR MATRIX PROTEIN 1; 1.
DR Pfam; PF05782; ECM1; 1.
DR SUPFAM; SSF48552; Serum albumin-like; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011596674"
FT REGION 19..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..118
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 61181 MW; 7C36AD25EE36AFB9 CRC64;
MGTMARVALV LACLAVASAT SEGGHEAPGQ KELRSEYIQE AGYAAPPSPP QARGFPVYHL
DPSQYDLPFE GQREVQSPPS PEAIPVQEEL PPPHLSNGKK VDPPLPPEAI PLQEELPPPH
PRTEQKEISQ SEEKPAPPMR QDPPEPHSWN PAQHCQQGRF RGGWGYRLDG FPPGRPSPDN
LNQICLPERQ HVVYGPWNLP QSGYSHLSRQ GETLNLLETG YSRCCRCRSH TNRLDCARLV
WEDAMTRFCE AEFSVKTRPH WCCRQQGEAR YSCFQEAAPQ PHYQLRACPT HQPGISLGLE
LPFPPGMPTL DNFKNICHLR RFRSVPRNLP ATDPIQRQLH ALTQLEMEFQ RCCRQGNNLT
CIWKAWEDTL DGYCDKEQAT KTHHHSCCHY PPSPARDECF AHQAPYPNYD RDILTLDLGR
VTPNLMGHLC GNRRVLTKHK QIPGLIQNMT ARCCNLPFPE QACCAEEEKS AFVEDLCGPR
RNFWRDSAFC CDLSPGDEQT NCFNINYLRN VALVAGDTGD ARGQGEQVPT GGTNISPTPE
SKEE
//
