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Database: UniProt
Entry: I3MCU2_ICTTR
LinkDB: I3MCU2_ICTTR
Original site: I3MCU2_ICTTR 
ID   I3MCU2_ICTTR            Unreviewed;      1833 AA.
AC   I3MCU2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSSTOP00000008103};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008103, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000008103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000008103}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AGTP01052575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01052576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000008103; -.
DR   Ensembl; ENSSTOT00000009041; ENSSTOP00000008103; ENSSTOG00000009013.
DR   eggNOG; ENOG410KCTY; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3MCU2; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    123    143       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    246    266       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    410    438       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    566    584       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    596    614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    634    655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    676    704       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    734    754       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    766    789       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1023   1041       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1062   1084       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1090   1110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1139   1165       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1263   1286       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1344   1362       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1374   1392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1404   1424       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1461   1489       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    443       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      567    793       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      803   1017       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1021   1295       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1343   1598       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       25     45       {ECO:0000256|SAM:Coils}.
FT   COILED      445    484       {ECO:0000256|SAM:Coils}.
FT   COILED     1286   1306       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1833 AA;  207610 MW;  C9CE43C0E39C5770 CRC64;
     MASSSLPTLV PIGPDCLRPF TRESLAAIER RAAEEEARLQ RNKQMEIEEP ERKPRSDLEA
     GKNLPLIYGD PPPEVIGIPL EDLDPYYSDK KTFIVLNKGK AIFRFSATPA LYMLSPFSIV
     RRGAIKVMFI MITILTNCVF MTMSDPPSWS KDVEYTFTGI YTFESLIKML ARGFCIDDFT
     FLRDPWNWLD FSVITMAYVT EFVDLGNISA LRTFRVLRAL KTITVIPGLK TIVGALIQSV
     KKLSDVMILT VFCLSVFALV GLQLFMGNLR QKCVRWPPPF NDTNTTWYGN DTWYANDTWY
     ANDTWNTNDT WNFHDSWASN YTFDWDAYIN DEANYYFLKD ANDALLCGNS SDAGHCPQGY
     ECIKAGRNPN YGYTSYDTFS WAFLALFRLM TQDYWENLFQ LTLRAAGKTY MIFFVVIIFL
     GSFYLINLIL AVVAMAYAEQ NEATLAEDQE KEEEFQQMLE KLKKHQEELE KAKATQALEG
     VEADGDPAHS QACNGSLDTS PGEKGPPRPS CSADSGISDA MEELEEAHQK CPPWWYKCAH
     KVLIWNCCTP WVKFKHIIHV IVMDPFVDLG ITICIVLNTL FMAMEHYPMT EHFDNVLSVG
     NLVFTGIFTA EMVLKLIAMD PYEYFQQGWN IFDSFIVTLS LVELGLANVQ GLSVLRSFRL
     LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KSYKECVCKI
     AADCSLPRWH MHDFFHSFLI VFRILCGEWI ETMWDCMEVA GQPMCLTVFL MVMVIGNLVV
     LNLFLALLLS SFSADSLAAS DEDGEMNNLQ IAIARIKWGI SFAKTFLLGL LHGKILSPKE
     IILSIGELGG AEQAGEAGEG APGDEKKEPP PEEGDKDLKK DNHILNHMGL ADGPPSSIEL
     DHLNFINNPY LTIQVPIASE ESDLEMPTEE ETDTFSEPED VKKPPQPLYD GNSSVCSTAD
     YKPPEEDPAE QAEEDPDGEQ PEECFTEACV QRCPCLYVDI SQGRGKMWWT LRRACFKIVE
     HNWFETFIVF MILLSSGALA FEDIYIEQRR VIRTILEYAD KVFTYIFILE MLLKWVAYGF
     KVYFTNAWCW LDFLIVDVSI ISLVANWLGY SELGPIKSLR TLRALRPLRA LSRFEGMRVV
     VNALLGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFYYC INTTTSERFD ISEVNNKSEC
     ESLMHTGQVR WLNVKVNYDN VGLGYLSLLQ VATFKGWMDI MYAAVDSREK EEQPQYEVNL
     YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN QQKKKMRKDI FMTEEQKKYY NAMKKLGSKK
     PQKPIPRPQN KIQGMVYDFV TKQVFDITIM ILICLNMVTM MVETDDQSQL KVDILYNINM
     VFIIIFTGEC VLKMFALRQY YFTVGWNIFD FVVVILSIVG LALSDLIQKY FVSPTLFRVI
     RLARIGRVLR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYSIFG MSNFAYVKKE
     SGIDDMFNFE TFGNSIICLF EITTSAGWDG LLNPILNSGP PDCDPTLENP GTSVRGDCGN
     PSIGICFFCS YIIISFLIVV NMYIAIILEN FNVATEESSE PLGEDDFEMF YETWEKFDPD
     ATQFIDYSRL SDFVDTLQEP LRIAKPNKIK LITLDLPMVP GDKIHCLDIL FALTKEVLGD
     SGEMDALKQT MEEKFMAANP SKVSYEPITT TLKRKHEEVC AIKIQRAYRR HLLQRSVKQA
     SYMYRHSQDG SGDGAPEKEG LIASTMSKMY GPENGDRAAQ SQGEETGPTT TGLTPVSPSD
     TTPPTPVSPS DAALPSSPPP GQTVRPGVKE SLV
//
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