ID I3MCV5_ICTTR Unreviewed; 203 AA.
AC I3MCV5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Helt bHLH transcription factor {ECO:0000313|Ensembl:ENSSTOP00000008121.3};
GN Name=HELT {ECO:0000313|Ensembl:ENSSTOP00000008121.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008121.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000008121.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01057163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MCV5; -.
DR STRING; 43179.ENSSTOP00000008121; -.
DR Ensembl; ENSSTOT00000009060.3; ENSSTOP00000008121.3; ENSSTOG00000009054.3.
DR eggNOG; KOG4304; Eukaryota.
DR GeneTree; ENSGT00940000160388; -.
DR HOGENOM; CLU_084227_0_0_1; -.
DR InParanoid; I3MCV5; -.
DR TreeFam; TF323617; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0021858; P:GABAergic neuron differentiation in basal ganglia; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF8; HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 48..83
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
SQ SEQUENCE 203 AA; 22482 MW; 95A55DAB2EFECDB5 CRC64;
MALAKQSSGK LEKAEILEMT VQYLRALHSA DFPRGREKEL LTEFANYFHY GYHECMKNLV
HYLTTVERME TKDTKYARIL AFLQSKARLG AEPAFPPLSS LPEPDFSYQL HPAGPEFAGH
SPGEATVFPQ GAAPGPFPWP HGTARSPALP YLPSAPVPLP SPAQQHSPFL TPVQGLDRHY
LNLIGHAHPN ALNLHTPQHP PVL
//
