ID I3MCW2_ICTTR Unreviewed; 800 AA.
AC I3MCW2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 6 {ECO:0000313|Ensembl:ENSSTOP00000008135.3};
GN Name=PCSK6 {ECO:0000313|Ensembl:ENSSTOP00000008135.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008135.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000008135.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; AGTP01015859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01015860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01015861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01015862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01015863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01015864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01015865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MCW2; -.
DR Ensembl; ENSSTOT00000009075.3; ENSSTOP00000008135.3; ENSSTOG00000009068.3.
DR GeneTree; ENSGT00940000159506; -.
DR HOGENOM; CLU_002976_3_0_1; -.
DR TreeFam; TF314277; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 4.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 326..466
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 762..800
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT ACT_SITE 110
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 151
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 325
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 800 AA; 89282 MW; 8B9E42E32DA93FB2 CRC64;
NLGQIGNLED YYHFYHSKTF KRSTLSSRGP HTFLRMDPQV KWLQQQEVKR RVKRQVRSDP
QALYFNDPIW SNMWYMHCGD KNSRCRSEMN VQAAWKRGYT GKNVVVTILD DGIERNHPDL
APNYDSYASY DVNGNDYDPS PRYDASNENK HGTRCAGEVA ASANNSYCIV GIAYNAKIGG
IRMLDGDVTD VVEAKSLGIK PNYIDIYSAS WGPDDDGKTV DGPGRLAKQA FEYGIKKGRQ
GLGSIFVWAS GNGGREGDYC SCDGYTNSIY TISVSSTTEN GHKPWYLEEC ASTLATTYSS
GAFYERKIVT TDLRQRCTDG HTGTSVSAPM VAGIIALALE AKSIPVVQVL RTTALTNACA
DHSDQRVIYL EHVVVRISIS HPRRGDLQIN LISPSGTKSQ LLAKRLLDFS NEGFTNWEFM
TVHCWGEKAE GEWTLEIQDM PSQIRNTEKQ GKLKEWSLIL YGTAEHPYQT FSSHQSRSRM
LELSTPQLEP PKAAKWLSQT EGLEDEEDYT APPIQVSPNV LQTSVCHPEC GNKGCNGPNA
DQCLNCVHFS LGNAKTSRKC VSSCPLGFFG DTAARRCRRC HKGCETCLGR NPTQCLSCRR
GFYHHQETNT CVTLCPAGFY ADESQKNCLK CHPSCKKCVD EPEKCTVCKE GFSLARGSCL
PDCEPGTYFD SELIRCGECH HTCRTCVGPS REECIHCAKN FHFQDWKCVP ACGEGFYPEE
MPGLPHKVCR RCEENCLSCE GSSRNCSKCK TGFTQLGTSC ITNHTCSNAD ETFCEMVKSN
RLCERKLFIQ FCCRTCLLAG
//
