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Database: UniProt
Entry: I3MD09_ICTTR
LinkDB: I3MD09_ICTTR
Original site: I3MD09_ICTTR 
ID   I3MD09_ICTTR            Unreviewed;      3551 AA.
AC   I3MD09;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=CUB and Sushi multiple domains 2 {ECO:0000313|Ensembl:ENSSTOP00000008207};
GN   Name=CSMD2 {ECO:0000313|Ensembl:ENSSTOP00000008207};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008207, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000008207}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AGTP01008148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01008157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000008207; -.
DR   Ensembl; ENSSTOT00000009154; ENSSTOP00000008207; ENSSTOG00000009074.
DR   eggNOG; KOG4297; Eukaryota.
DR   eggNOG; ENOG410XPJ1; LUCA.
DR   GeneTree; ENSGT00940000159768; -.
DR   InParanoid; I3MD09; -.
DR   TreeFam; TF316872; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 28.
DR   CDD; cd00041; CUB; 14.
DR   Gene3D; 2.60.120.290; -; 14.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00431; CUB; 14.
DR   Pfam; PF00084; Sushi; 27.
DR   SMART; SM00032; CCP; 28.
DR   SMART; SM00042; CUB; 14.
DR   SUPFAM; SSF49854; SSF49854; 14.
DR   SUPFAM; SSF57535; SSF57535; 28.
DR   PROSITE; PS01180; CUB; 14.
DR   PROSITE; PS50923; SUSHI; 28.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3475   3496       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       11    119       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      122    183       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      187    291       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      326    387       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      390    501       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      504    561       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      563    671       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      674    735       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      737    845       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      850    907       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      909   1019       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1022   1081       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1083   1191       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1194   1254       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1256   1365       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1368   1428       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1430   1538       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1541   1602       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1604   1712       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1718   1779       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1781   1889       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1892   1951       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1953   2061       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2064   2123       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2125   2236       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2235   2296       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2298   2409       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2409   2471       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2472   2533       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2534   2598       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2599   2656       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2657   2714       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2715   2772       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2773   2835       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2836   2893       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2897   2954       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2955   3013       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3014   3073       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3074   3131       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3132   3189       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3193   3251       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3252   3311       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID    532    559       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    878    905       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   1256   1283       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID   2627   2654       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2685   2712       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2743   2770       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2806   2833       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2864   2891       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2925   2952       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2984   3011       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   3102   3129       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   3160   3187       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   3222   3249       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   3551 AA;  386496 MW;  0C344CC18AF1746A CRC64;
     MPRSRGRGQN CTFQLQGPNG TVESPGFPYG YPNYANCTWT ITAEDQHRIQ LVFQSFALEE
     DFDVLSVFDG PPQPENLRTR LTGFQLPATI VSMATILSLR LISDYAVSAQ GFHASYEVLP
     SHTCGNPGRL PNGIQQGSTF NLGDKVRYSC HPGFFLEGHA VLTCHAGSEN SATWDFPLPS
     CRADDACGGT LRGQSGIISS PHFPSEYHNN ADCTWTILAE LGDTIALVFI DFQLEDGYDF
     LEVTGTEGSS LWFTGASLPA PVISSKNWLR LHFTADGNHR QRGFSAQYQV KKQIELKSRG
     VKLMPSKDSS RKTSVLTQVG VSQGHNMCPD PGIPERGKRL GSDFRLGSSV QFTCNEGYDL
     QGSKRITCMK VSDMFAAWSD HRPICRARMC DAHLRGPSGI ITSPNFPIQY DNNAHCVWII
     TALNPAKVIK LAFEEFDLER GYDTLTVGDG GQDGDQKTVL YILTGTSVPD LIVSTNHQMW
     LLFQTDGSGS SLGFKASYEE IEQGSCGDPG IPAYGRREGS RFRHGDTLKF ECQPAFELVG
     QKAITCQKNN QWSAKKPGCV FSCFFNFTSP SGVVLSPNYP EDYGNHLHCV WLILARPESR
     IHLAFNDIDV EPQFDFLVIK DGATAEAPVL GTFSGNQLPS SITSSGHVAR LEFQTDHSTG
     KRGFNITFTT FRHNECPDPG VPVNGKRFGD SLQLGSSISF LCDEGFLGTQ GSETITCILK
     EGSVVWNSAV LRCEAPCGGH LTSPSGTILS PGWPGFYKDA LSCAWVIEAQ PGYPIKITFD
     RFKTEVNYDT LEVRDGRTYS APLIGVYHGT QVPQFLISTS NYLYLLFSTD KSHSDIGFQL
     RYETITLQSD HCLDPGIPVN GQRHGNDFYV GALVTFSCDS GYTLSDGEPL ECEPNFQWSR
     ALPSCEALCG GFIQGSSGTI LSPGFPDFYP NNLNCTWVIE TSHGKGVFFT FHTFHLESGH
     DYLLLTENGS FTQPLRQLTG SRLPAPISAG LYGNFTAQVR FISDFSMSYE GFNITFSEYD
     LEPCEEPEVP AYSIRKGLQF GVGDTLTFSC FPGYRLEGTA RITCLGGRRR LWSSPLPRCV
     AECGNSVTGT QGTLLSPNFP VNYNNNHECI YSIQTQPGKG IQLKARAFEL SEGDVLKVYD
     GNNNSARLLG VFSRSEMLGV TLNSTSSSLW LDFITDAENT SQGFELQFSS FELIKCEDPG
     TPQFGYKVHD GGHFAGSSVS FSCDPGYSLR GSQELQCLSG ERRTWDRPLP TCVAECGGTV
     KGEVSGQVLS PGYPAPYEHN LNCIWTVEAD AGCTIGLHFL VFDTEEVHDV LRIWDGPVES
     GVLLKELSGS VLPKDLHSTF NSVVLQFSTD FFTSKQGFAI QFSVSTATSC NDPGVPQNGS
     RSGNSWEAGD STVFQCDPGY ALQGSAEISC VKIENRFFWQ PSPPTCIAPC GGDLTGPSGV
     ILSPNYPEPY PPGKECDWKV TVSPDYVIAL VFNIFNLEPG YDFLHIYDGR DSLSPLIGSF
     YGSQLPGRIE SSGNSLFLAF RSDASVSNAG FVIDYTENPR ESCFDPGSIK NGTRVGSDLK
     LGSSITYYCH GGYEVEGSST LSCILGPDGK PVWNNPRPVC TAPCGGQYVG SDGVVLSPNY
     PQNYTSGQIC LYFVTVPKDY VVFGQFAFFH TALNDVVEVH DGHSQHSRLL SSLSGSHTGE
     SLPLATSNQV LIKFSAKGQA PARGFHFVYQ AVPRTSATQC SSVPEPRYGK RLGSDFSVGA
     IVRFECNSGY ALQGSPEIEC LPVPGALAQW NVSAPTCVVP CGGNLTERKG TILSPGFPEP
     YLNSLNCVWK IMVPEGAGIQ IQVISFVTEQ NWDSLEVFDG ADNTVTMLGS FSGTTMPALL
     NSTSNQLYLH FYSDISVSAA GFHLEYKTVG LSSCPEPAVP SNGVKTGERY LVNDVVSFQC
     EPGYALQGHA HISCMPGTVR RWNYPPPLCI AQCGGAVEEL EGVILSPGFP GNYPSNMDCS
     WKIALPVGFG AHIQFLNFST EPNHDFIEIR NGPYETSRMM GRFSGSELPS TLLSTSHETT
     VYFHSDHSQN RPGFKLEYQA YELQECPDPE PFANGIVRGA GYNVGQSVTF ECLPGYQLTG
     HPVLTCQHGT NRNWDHPLPR CEVPCGGNIT SSNGTVYSPG YPSPYSSSQD CVWMITVPIG
     HGVRLNLSLL QTEPSGDFIT IWDGPQQTSP QLGVFTRSLA KKTVHSSTNQ VLLKFHHDAA
     LGGIFAIAFS AYPLTKCPPP TILPNAEVVT ENEEFNIGDI VRYRCLPGFT LVGNEILTCK
     LGTSLQFEGP PPICEVHCPT NELLTDSTGV ILSQSYPGSY PQFQTCSWLV KVEPEYNISL
     TVEYFLSEKQ YDEFEIFDGP SGQSPLLKAL SGNYSAPLIV TSSSNSVYLR WSSDHAYNRK
     GFKIRYSAPY CSLPRAPLHG FILGQTSTQP GGSIHFGCNT GFRLVGHSMA ICTRHPQGYH
     LWSEAIPLCQ ALSCGLPDAP KNGMVFGKEY TVGTKAVYSC SEGYHLEAGA DATAECLETG
     LWSNHNVPPQ CVPVTCPDVS SISVEHGRWR LIFETQYQFQ AQLMLICDPG YYYTGQRVIR
     CQANGKWSLG DSMPTCQITS CGELPTPPSG HRIGTLSVYG ATAIFSCNSG YTLVGSRVRE
     CLANGLWSGS EVRCLAGHCG TPEPIVNGHI NGENYNYRGS VVYQCNAGFR LIGMSVRICQ
     QDHHWSGKTP FCVPITCGHP GNPINGLTHG SQFNLNDVVK FVCNPGYVAE GASRSQCLAS
     GQWSDMLPTC RIINCTDPGH QENSIRQVHA SGPHRFSFGT SVSYQCNHGF YLLGSPVLSC
     QGDGTWDRPR PQCLLVSCGH PGSPPHSQMS GDSYIVGAVV RYSCTGKRTL VGNATRMCGL
     DGHWTGSLPH CSGTSTGVCG DPGIPAHGIR LGDSFAPGSL MRFSCEAGHV LRGSSERTCQ
     ANGSWSGTQP ECGVISCGNP GTPSNARVMF SDGLVFSSSI VYECREGYYA TGLLSRHCSV
     NGTWTGSDPE CTVINCGDPG IPANGLRLGN DFRYNKTVTY QCIPGYMMES HRVSVLSCTK
     DRTWNGTKPV CKAIMCKPPQ LIPNGKVVGS DFMWGSSVTY ACLEGYQLSL PAVLTCEGNG
     SWTGELPQCF PVFCGDPGVP PRGRREDRGF SYRSSVSYSC HPPLVLVGSP RRFCQSDGTW
     SGTQPSCIDP TLTMCADPGV PQFGIQNNSQ GYQVGSTVLF RCQKGYLLQG STTRTCLPNL
     TWSGTPPDCV PHHCKQPETP THANVGALDL PSMGYTLIYS CQEGFSLKGG SEHRTCRADG
     SWTGKPPICL EVRPSGRPIN TAREPPLTQA SVPGDVFAKN SLWKGAYEYQ GKKQPAMLRV
     TGFQAANSKV NATMIDHSGV ELHLAGYYKK EDFHLLLQVY QVTGPVEIFV NKFKDDHWAL
     DGHVSSESAG GTFIYQGSVK GQGFGQFGFQ RLDLRLLESD PESIGRHFAS NSSSVAAAIL
     VPFIALIIAG FVLYLYKHRR RPKVPFNGYA GHENTNVRAT FENPMYDRNI QPTDIMASEA
     EFTVSTVCTA V
//
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