ID   I3MDQ5_ICTTR            Unreviewed;       186 AA.
AC   I3MDQ5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Prolactin {ECO:0000256|ARBA:ARBA00041065};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008549.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000008549.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation. {ECO:0000256|ARBA:ARBA00037239}.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000256|ARBA:ARBA00038619}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|ARBA:ARBA00008474}.
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DR   EMBL; AGTP01142795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01142796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3MDQ5; -.
DR   Ensembl; ENSSTOT00000009530.3; ENSSTOP00000008549.3; ENSSTOG00000009534.3.
DR   GeneTree; ENSGT00950000182818; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   PANTHER; PTHR11417:SF5; PROLACTIN; 1.
DR   PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Lactation {ECO:0000256|ARBA:ARBA00043262};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601400-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Zinc {ECO:0000256|PIRSR:PIRSR601400-1}.
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601400-1"
SQ   SEQUENCE   186 AA;  20308 MW;  54EE210040434ED2 CRC64;
     LLCKNVASLP ICPSGAVNCQ VSLRDLFDRA VILSHYIHNL SSEMFNEFDV RFLTRAALTR
     VDDSAAALLI SAASNGSLNV APQHEDLLNL VLRVLRSWND PLYHLVSEVR GMHEAPDAIL
     SKAIEIEEQN KRLLEGMEKI VGQISPPGAP ADLLSEGSGL SVGNQSSSTS LGRNETWCSF
     SRRLLK
//