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Database: UniProt
Entry: I3MDW3_ICTTR
LinkDB: I3MDW3_ICTTR
Original site: I3MDW3_ICTTR 
ID   I3MDW3_ICTTR            Unreviewed;      4615 AA.
AC   I3MDW3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Dynein cytoplasmic 1 heavy chain 1 {ECO:0000313|Ensembl:ENSSTOP00000008629.3};
GN   Name=DYNC1H1 {ECO:0000313|Ensembl:ENSSTOP00000008629.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008629.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000008629.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; AGTP01111535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01111536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000008629; -.
DR   Ensembl; ENSSTOT00000009619.3; ENSSTOP00000008629.3; ENSSTOG00000009558.3.
DR   eggNOG; KOG3595; Eukaryota.
DR   GeneTree; ENSGT00940000156103; -.
DR   HOGENOM; CLU_000038_1_2_1; -.
DR   InParanoid; I3MDW3; -.
DR   TreeFam; TF335573; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IEA:Ensembl.
DR   GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:Ensembl.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:Ensembl.
DR   GO; GO:0051293; P:establishment of spindle localization; IEA:Ensembl.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   GO; GO:0033962; P:P-body assembly; IEA:Ensembl.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0032388; P:positive regulation of intracellular transport; IEA:Ensembl.
DR   GO; GO:1905832; P:positive regulation of spindle assembly; IEA:Ensembl.
DR   GO; GO:0090235; P:regulation of metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; IEA:Ensembl.
DR   GO; GO:0034063; P:stress granule assembly; IEA:Ensembl.
DR   CDD; cd00009; AAA; 2.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 2.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 1.20.920.60; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 4.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1870..2014
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2185..2336
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2556..2706
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2898..3064
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2359..2380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1155..1182
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3174..3222
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3371..3468
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2359..2377
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4615 AA;  529149 MW;  31306A3FAA81FE6D CRC64;
     LRFHPGGQAR SASAGLTVRR LGPRPDGGEA PAALEAALEE KSALEQMRKF LSDPQVHTVL
     VERSTLKEDV GDEGEEEKEF ISYNINIDIH YGVKSNSLAF IKRTPVIDAD KPVSSQLRVL
     TLSEDSPYET LHSFISNAVA PFFKSYIRES GKADRDGDKM APSVEKKIAE LEMGLLHLQQ
     NIEIPEISLP IHPIITNVAK QCYERGEKPK VTDFGDKVED PTFLNQLQSG VNRWIREIQK
     VTKLDRDPAS GTALQEISFW LNLERALYRI QEKRESPEVL LTLDILKHGK RFHATVSFDT
     DTGLKQALET VNDYNPLMKD FPLNDLLSAT ELDKIRQALV AIFTHLRKIR NTKYPIQRAL
     RLVEAISRDL SSQLLKVLGT RKLMHVAYEE FEKVMVACFE VFQTWDDEYE KLQVLLRDIV
     KRKREENLKM VWRINPAHRK LQARLDQMRK FRRQHEQLRA VIVRVLRPQV TAVAQQNQGE
     VPEPQDMKVA EVLFDAADAN AIEEVNLAYE NVKEVDGLDV SKEGTEAWEA AMKRYDERID
     RVETRITARL RDQLGTAKNA NEMFRIFSRF NALFVRPHIR GAIREYQTQL IQRVKDDIES
     LHDKFKVQYP QSQACKMSHV RDLPPVSGSI IWAKQIDRQL TAYMKRVEDV LGKGWENHVE
     GQKLKQDGDS FRMKLNTQEI FDDWARKVQQ RNLGVSGRIF TIESTRVRGR TGNVLKLKVN
     FLPEIITLSK EVRNLKWLGF RVPLAIVNKA HQANQLYPFA ISLIESVRTY ERTCEKVEER
     NTISLLVAGL KKEVQALIAE GIALVWESYK LDPYVQRLAE TVFNFQEKVD DLLIIEEKID
     LEVRSLETCM YDHKTFSEIL NRVQKAVDDL NLHSYSNLPI WVNKLDMEIE RILGVRLQAG
     LRAWTQVLLG QAEDKAEVDM DTDAPQVSHK PGGEPKIKNV VHELRITNQV IYLNPPIEEC
     RYKLYQEMFA WKMVVLSLPR IQSQRYQVGV HYELTEEEKF YRNALTRMPD GPVALEESYS
     AVMGIVTEVE QYVKVWLQYQ CLWDMQAENI YNRLGEDLNK WQALLVQIRK ARGTFDNAET
     KKEFGPVVID YGKVQSKVNL KYDSWHKEVL SKFGQMLGSN MTEFHSQISK SRQELEQHSV
     DTASTSDAVT FITYVQSLKR KIKQFEKQVE LYRNGQRLLE KQRFQFPPSW LYIDNIEGEW
     GAFNDIMRRK DSAIQQQVAN LQMKIVQEDR AVESRTTDLL TDWEKTKPVT GNLRPEEALQ
     ALTIYEGKFG RLKDDREKCA KAKEALELTD SGLLSGSEER VQVALEELQD LKGVWSELSK
     VWEQIDQMKE QPWVSVQPRK VGLYQLQTSF RNLAKFIRCH LMSYVNMLVI ELKSEALKDR
     HWKQLMKRLH VNWVVSELTL GQIWDVDLQK NEAIVKDVLL VAQGEMALEE FLKQIREVWN
     TYELDLVNYQ NKCRLIRGWD DLFNKVKEHI NSVSAMKLSP YYKVFEEDAL SWEDKLNRIM
     ALFDVWIDVQ RRWVYLEGIF TGSADIKHLL PVETQRFQSI STEFLALMKK VSKSPLVMDV
     LNIQGVQRSL ERLADLLGKI QKALGEYLER ERSSFPRFYF VGDEDLLEII GNSKNVAKLQ
     KHFKKMFAGV SSIILNEDNS VVLGISSREG EEVMFKTPVS ITEHPKINEW LTLVEKEMRV
     TLAKLLAESV TEVEIFGKAT SIDPNTYITW IDKYQAQLVV LSAQIAWSEN VESALSNVGG
     GGDAAPLHSV LSNVEATLNV LADSVLMEQP PLRRRKLEHL ITELVHQRDV TRSLIKSKID
     NAKSFEWLSQ MRFYFDPKQT DVLQQLSIQM ANAKFNYGFE YLGVQDKLVQ TPLTDRCYLT
     MTQALEARLG GSPFGPAGTG KTESVKALGH QLGRFVLVFN CDETFDFQAM GRIFVGLCQV
     GAWGCFDEFN RLEERMLSAV SQQVQCIQEA LREHSNPNYD KTSAPITCEL LNKQVKVSPD
     MAIFITMNPG YAGRSNLPDN LKKLFRSLAM TKPDRQLIAQ VMLYSQGFRT AEVLANKIVP
     FFKLCDEQLS SQSHYDFGLR ALKSVLVSAG NVKRERIQKI KREKEERGEA VDEGEIAENL
     PEQEILIQSV CETMVPKLVA EDIPLLFSLL SDVFPGVQYH RGEMTALREE LKKVCQEMYL
     TYGDGEEVGG MWVEKVLQLY QITQINHGLM MVGPSGSGKS MAWRVLLKAL ERLEGVEGVA
     HIIDPKAISK DHLYGTLDPN TREWTDGLFT HVLRKIIDNV RGELQKRQWI VFDGDVDPEW
     VENLNSVLDD NKLLTLPNGE RLSLPPNVRI MFEVQDLKYA TLATVSRCGM VWFSEDVLST
     DMIFNNFLAR LRSIPLDEGE DEAQRRRKGK EDEGEEAASP MLQIQRDAAT IMQPYFTSNG
     LVTKALEHAF QLEHIMDLTR LRCLGSLFSM LHQACRNVAQ YNANHPDFPM QIEQLERYIQ
     RYLVYAILWS LSGDSRLKMR AELGEYIRRI TTVPLPTAPN IPIIDYEVSI SGEWSPWQAK
     VPQIEVETHK VAAPDVVVPT LDTVRHEALL YTWLAEHKPL VLCGPPGSGK TMTLFSALRA
     LPDMEVVGLN FSSATTPELL LKTFDHYCEY RRTPNGVVLA PVQLGKWLVL FCDEINLPDM
     DKYGTQRVIS FIRQMVEHGG FYRTSDQTWV KLERIQFVGA CNPPTDPGRK PLSHRFLRHV
     PVVYVDYPGP ASLTQIYGTF NRAMLRLIPS LRTYAEPLTA AMVEFYTMSQ ERFTQDTQPH
     YIYSPREMTR WVRGIFEALR PLETLPVEGL IRIWAHEALR LFQDRLVEDE ERRWTDENID
     MVALKHFPNI DKEKAMSRPI LYSNWLSKDY IPVDQEELRD YVKARLKVFY EEELDVPLVL
     FNEVLDHVLR IDRIFRQPQG HLLLIGVSGA GKTTLSRFVA WMNGLSVYQI KVHRKYTGED
     FDEDLRTVLR RSGCKNEKIA FIMDESNVLD SGFLERMNTL LANGEVPGLF EGDEYATLMT
     QCKEGAQKEG LMLDSHEELY KWFTSQVIRN LHVVFTMNPS SEGLKDRAAT SPALFNRCVL
     NWFGDWSTEA LYQVGKEFTS KMDLEKPNYI VPDYMPVVYD KLPQPPSHRE AIVNSCVFVH
     QTLHQANARL AKRGGRTMAI TPRHYLDFIN HYANLFHEKR SELEEQQMHL NVGLRKIKET
     VDQVEELRRD LRIKSQELEV KNAAANDKLK KMVKDQQEAE KKKVMSQEIQ EQLHKQQEVI
     ADKQMSVKED LDKVEPAVIE AQNAVKSIKK QHLVEVRSMA NPPAAVKLAL ESICLLLGES
     TTDWKQIRSI IMRENFIPTI VNFSAEEISD AIREKMKKNY MSNPSYNYEI VNRASLACGP
     MVKWAIAQLN YADMLKRVEP LRNELQKLED DAKDNQQKAN EVEQMIRDLE ASIARYKEEY
     AVLISEAQAI KADLAAVEAK VNRSTALLKS LSAERERWEK TSETFKNQMS TIAGDCLLSA
     AFIAYAGYFD QQMRQNLFTT WSHHLQQANI QFRTDIARTE YLSNADERLR WQASSLPADD
     LCTENAIMLK RFNRYPLIID PSGQATEFIM NEYKDRKITR TSFLDDAFRK NLESALRFGN
     PLLVQDVESY DPVLNPVLNR EVRRTGGRVL ITLGDQDIDL SPSFVIFLST RDPTVEFPPD
     LCSRVTFVNF TVTRSSLQSQ CLNEVLKAER PDVDEKRSDL LKLQGEFQLR LRQLEKSLLQ
     ALNEVKGRIL DDDTIITTLE NLKREAAEVT RKVEETDIVM QEVETVSQQY LPLSTACSSI
     YFTMESLKQI HFLYQYSLQF FLDIYHNVLY ENPNLKGITD HTQRLSIITK DLFQVAFNRV
     ARGMLHQDHI TFAMLLARIK LKGTMGEPTY DAEFQHFLRG KEMVLSAGST PKIQGLTVEQ
     AEAVVRLSCL PAFRDLISKI QADEQFGIWL DSSSPEQTVP YLWSEETPAT PIGQAVHRLL
     LIQAFRPDRL LAMAHVFVST NLGESFMSIM EQPLDLTHIV GTEVKPNTPV LMCSVPGYDA
     SGHVEDLAAE QNTQITSIAI GSAEGFNQAD KAINTAVKSG RWVMLKNVHL APGWLMQLEK
     KLHSLQPHAC FRLFLTMEIN PKVPVNLLRA GRIFVFEPPP GVKANMLRTF SSIPVSRICK
     SPNERARLYF LLAWFHAVIQ ERLRYAPLGW SKKYEFGESD LRSACDTVDT WLDDTAKGRQ
     NISPDKIPWS ALKTLMAQSI YGGRVDNEFD QRLLNTFLER LFTTRSFDSE FKLACKVDGH
     KDIQMPDGIR REEFVQWVEL LPDTQTPSWL GLPNNAERVL LTTQGVDMIS KMLKMQMLED
     EDDLAYAETE KKTRTDSTSD GRPAWMRTLH TTASNWLHLI PQTLSHLKRT VENIKDPLFR
     FFEREVKMGA KLLQDVRQDL ADVVQVCEGK KKQTNYLRTL INELVKGILP RSWSHYTVPA
     GMTVIQWVSD FSERIKQLQN ISLAAASGGA KELKNIHVCL GGLFVPEAYI TATRQYVAQA
     NSWSLEELCL EVNVTTSQSA TLDACSFGVT GLKLQGATCS NNKLSLSNAI STVLPLTQLR
     WVKQTSPEKK ANVVTLPVYL NFTRADLIFT VDFEIATKED PRSFYERGVA VLCTE
//
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