ID I3MEC3_ICTTR Unreviewed; 390 AA.
AC I3MEC3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=HS3ST3B1 {ECO:0000313|Ensembl:ENSSTOP00000008830.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008830.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000008830.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; AGTP01099646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005338914.1; XM_005338857.2.
DR AlphaFoldDB; I3MEC3; -.
DR STRING; 43179.ENSSTOP00000008830; -.
DR Ensembl; ENSSTOT00000009846.3; ENSSTOP00000008830.2; ENSSTOG00000009851.3.
DR GeneID; 101968186; -.
DR CTD; 9953; -.
DR eggNOG; KOG3704; Eukaryota.
DR GeneTree; ENSGT00940000162568; -.
DR HOGENOM; CLU_017703_0_1_1; -.
DR InParanoid; I3MEC3; -.
DR OMA; ELSHYMP; -.
DR OrthoDB; 10019at2759; -.
DR TreeFam; TF350755; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008467; F:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; IEA:Ensembl.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF7; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3B1; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 138..373
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 147
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 147..151
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 228
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 236
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 353..357
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 336..348
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 390 AA; 43188 MW; BB48331DCEF665CB CRC64;
MGQRLSGGRS CLDVPGRFLP QPPTPPPPVR RKLALLFAML CVWLYMFLYS CAGSCAAAPG
LLLLGSGSRT AHAPPALATA PNGTPPRLPF RAPPATALAA GKEMAEGAAS LEEQSRETPD
SPSSISSFFS GSGTKQLPQA IIIGVKKGGT RALLEFLRVH PDVRAVGAEP HFFDRSYDKG
LAWYRDLMPR TLEGQITMEK TPSYFVTREA PARISAMSKD TKLIVVVRDP VTRAISDYTQ
TLSKRPDIPT FESLTFKNRS TGLIDTSWSA IQIGIYAKHL EHWLRHFPIG QMLFVSGERL
ISDPAGELGR VQDFLGLKRI ITDKHFYFNK TKGFPCLKKA EGSSKPHCLG KTKGRTHPQI
AQEVVQRLRE FYRPFNLKFY QMTGHDFGWD
//
