ID I3MEQ5_ICTTR Unreviewed; 789 AA.
AC I3MEQ5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G6 {ECO:0000313|Ensembl:ENSSTOP00000009014.3};
GN Name=PLEKHG6 {ECO:0000313|Ensembl:ENSSTOP00000009014.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009014.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000009014.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01097485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005338419.1; XM_005338362.2.
DR AlphaFoldDB; I3MEQ5; -.
DR STRING; 43179.ENSSTOP00000009014; -.
DR Ensembl; ENSSTOT00000010050.3; ENSSTOP00000009014.3; ENSSTOG00000010044.3.
DR eggNOG; KOG3521; Eukaryota.
DR GeneTree; ENSGT00940000161250; -.
DR HOGENOM; CLU_021968_1_0_1; -.
DR InParanoid; I3MEQ5; -.
DR TreeFam; TF316755; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042918; PLEKHG6.
DR PANTHER; PTHR47671; PLECKSTRIN DOMAIN-CONTAINING FAMILY G MEMBER 6; 1.
DR PANTHER; PTHR47671:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 6; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 161..353
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 409..509
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 89009 MW; 417742BF8D732BDD CRC64;
MQGFSPPDES PLQGLVASRI ETYGGRRQAS TQSPAGGLYS RGSPVLDPSR RRFPHYVPFV
KGSGPSRGLS PLMLREQELE KKHGGHLGPG PPHSPKLKEV TKAHELELRL HTFSMFGMPR
LPPEDRQYWE IGEGGDSGVT IEKSWRELVP GHKEMSREQC HQQEALWELL TTELIYVRKL
KIMTDLLAAG LLNLQRVGLL MEVSAETLFG NVPSLIRAHR RFWEEVLEPF LEETRASGQP
LDPIRLQNGF LMFGQWFQPY VQYCLRVKQI MAYAREQQDT NLLFHTFVQW CEKHKRSGRQ
MLGDLLIKPH QRITKYPLLL QAVLKRSPEA RVREALDAMI AAVESFLRHI NGQVRQGEEQ
ESLVAAAQRI GNYEVLEASS EEVEKNLRPF CTLDLMSPML GVGPEHTRQL LLEGPVRVKE
GREGKLDVYL FLFSDVLLVT KPQRKVDKAK VIRPPLMLEK LVCRPLRDPN SFLVIHLTEF
QCVSSALVVH CPSSTDRARW LEKTQQAQAA LQKLKAEEYV QQKRELLALY RDQGRESPST
RPSTPSPEGS QSSAEGRTPE FTVIIPHLVV TEDTDEDAPS VPDDTSDSGY GTLMSSSPKA
SHSRLSRLRP RALKRDPRLT FSTLDLRNVP LRPQPADPQA PQRRSAPELP EGIQRGGSLP
RVDPPTWSEE EDGSSAGRNV VAETLHRAQL RGQLPSSPNH TDSAGESPWE SSEEDEGPLF
LGPGYSPCSR PLRAEDMLRE IREELASQRI EGAPEPRDSR PRKLTRAQLQ RMRGHHIIKL
DTPLSTSEV
//
