ID I3MFN6_ICTTR Unreviewed; 3134 AA.
AC I3MFN6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=WDFY family member 4 {ECO:0000313|Ensembl:ENSSTOP00000009449.3};
GN Name=WDFY4 {ECO:0000313|Ensembl:ENSSTOP00000009449.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009449.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000009449.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01100045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01100046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01100047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01100048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01100049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000009449; -.
DR Ensembl; ENSSTOT00000010530.3; ENSSTOP00000009449.3; ENSSTOG00000010515.3.
DR eggNOG; KOG1786; Eukaryota.
DR eggNOG; KOG1788; Eukaryota.
DR GeneTree; ENSGT00940000155684; -.
DR HOGENOM; CLU_000175_5_2_1; -.
DR InParanoid; I3MFN6; -.
DR TreeFam; TF313658; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2335..2460
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2477..2771
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2928..2962
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1786..1819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2262..2291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2764..2789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3059..3078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1786..1804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3134 AA; 350428 MW; 209D5901A0918553 CRC64;
MEAEDLSKAE EGPEDPGLKN EGQSAAVQPE YPLGRQSPGP TDLWDMLERK FLEYQQMTYG
SADERRKSLL CLLPLFLKAW EHSVGIICFP SLQRLAEDVS DQLAQEIQKA LAGKPAEQAR
VVAGQLLRCK GDVDRDGYLL LKSVYVLTGT DSETLGRVAE SGLPALLLQC LYLFFIFPLE
KDENDVQGQR MFVQMLLNIC SESQGLEGFL SGCELQSLLI ATTCLREHSC YFWKEPTFCV
LKAISRAQSP SIIQYLQAAD CVRLSVQNLS RLADTLPPPE VSEAVNLILG FVKDSYPIST
TLLLEFENGE GYPLLLKVLL RYDGLTQGEV DPHLEELVGL VVWLTTCGRS ELKVFDSVTY
PQLEGFKFHR ETSGVSVKNL QAFQVLQSVF HKANDAVLCM QVLLAIKTMW AWNPWNFFLL
EWTLQPISQF VEIVPLKPTP VQVQFFQLLE SLVFKMCYVP HEILQKVQRL IKESPEPSCT
LVALQSILKI TGSDPLFTDI FRDSGLLGLL LAQLRKQAKI MRKSGNKEYS PGIQDPEREL
TCVMLRTVVA LLKGSVRNAV VLKDHGMVPF IKIFLDDECY RGASLSILEQ LSVINAEEYM
SIIVGALCSS TQGELQLKLD LLKSLLRILE TPKGRAAFRV SSGFNGLLSL LSDLEGSLHE
PPLQVWGTVT PSQTLELVLH TLCAVSAALH LDPVNSDFFR RNGLFEKLAE DLYLLGCFGV
LIKEGPSRHS WSDTKARPFA DFLSAAFSSR CPLPPRIQRC LQILSFLDSM ASGILHLRRD
LKDSLRAGQE SVVDVQKGNA ISNLQGNFKW LDPEERMDEG DSVIMHPGMV CVMVKLLPRL
YHEDHPQLSE EIQCSMASHL QSLVKSEKNR QVMCEAGMLR TLMTSCGWAL STSSSPLHSH
LIRIFEKLAS QAIEPDVLRY HGKASPNSGV AQSLRSSEAS QDSTTALQTA LSLISMTSPR
NLQPQRAALA PSFVEFDMSV EGYGCLFIPT LSTVMGINTE YSVSGGIGTG AARSFPPPGG
LTFSCWFLIS RQAAITEGHP LRFLTLVRHL ARTEQPFVCF SVSLCPDDLS LVVSTEEKEF
QPLDIMEPED ESEPSAGCQL QVRCGQLLAC GQWHHLAVVV TKEMKRNCIV STYLDGQVIG
SAKMLYIQAL PGPFLSMDPS SFVDVYGYIA TPRIWKQKSS LIWRLGPSYL FEEAISPDTL
EVIIKLGPRY CGNFQAVHDQ GGDPAGQATP LVAEEKISFG LHVTSSSITT VADIRNAYNE
VDSRLIAKEM NISSRDNAMP VFLLRNCAGH LSGFLRTLGA VAVGQLGVRV FHSSPAACSL
DFIGGPTILL GLISLAKDDH TMYAAVKVLH SVLTSNAMCD RLMQHICGYQ IMAFLLRKKT
SLLNHRIFQL ILSVAGTAEL GFRSSAITNI SVFQHILCNF ELWMNTADNL ELALFSHLVE
ILQSPREGPR NAEVAHQAQL IPQLVFLFNE PRLAPSKIPT IIAILDCQLK SHFSICDVLR
IGLFIVYTLK PSSVNERQIC VDGAQELSMP AGSQTSGKTI WLRNQLLEML LSVISSPQLH
LSSESKEEMF LNLGPDWFLL LLQGHLHAST TVLALKLLLH FLSNPSLRGR FKDGLPVGSW
VERSTEGMNI VMDNLKSHPS VPDQSPRLLP GFRVLTAFLA LHVHIPEVYL IVSTFFLQTS
LTELMDCPKD SLDAMLHWLL KNHHQQEVLR DGLCTEGALL LLEMLKATMS QPLTGSEDSI
WEQTFPVTVL HFLSLVHRTY SQDPAWRAPE FLQTLAIVTF PLGTQKGPSA ESTWNTSSPG
TVSEGDSPKE GLQAPVKSHP ARRQLRDFTQ ILLRELLLGT PSPKQWLPLE VLLEACPDNA
TSQQKRDFQS EVLLSTMEIF HIMSGGNMAL RGSKEPQPNI EAAAAPSLSN ISYFTQKLVE
KLYGGIFSAD PRHILLFITE HIMVIENTSS QRETVISALY SSLNKVILYC LSKPQQSLSE
CLSLLSILGF LQEHWDIIFA TYNSNVSFLL CLMHCLLLLN ERSYPEGFGL EPKPRMTPYH
QVFLSPNEEV KEKTEENVPS LSDVQHNIQK TVQTLWQQLV AQRRQALEDT FKIDLSVKPG
ESEVKIEEVT PLWEETMLKS WQHYLASEKK SLASRSSVTH QSKVTSWSES LSSAMRLMPG
RQARDPECKA EDFVSCIENY RRKGQELYAS LYKDHVQRRR CCNIKAANAW ARIREQLFGE
LGLWGQMAET TFCSRWELDW REGPARMKKR IRRLSPWEVR SPEKCKEGQD RKGDISQINA
EKQDELTPKE AESEPVEVAV DCTQLTFFPA LHESLHSEDF LELCRERQVI LQELLDQEKV
TQKLSLVIVQ GHLVSEGVLL FGHQHFYICE NFTLSPTGDV YCTRHCLSNI SDSFIFNMCS
KDRSSDHYSC QRHSYWDLRE LRQARFLLQD IALELFFQNG YSKFLVFYNS DRSRAFKSFC
SFQPSLKGKG VTEDPLNLRK YPSFDRTMLQ RWQKRDISNF EYLMYLNTLA GRTYNDYMQY
PVFPWVLADY TSEVLNLTNP KTFRDLSKPM GAQTKERKLK FIQRFKEVEK TEGDMTVQCH
YCTHYSSAII VASYLVRMPP FTQAFCSLQG GSFDVADRMF HSMKSAWESA SRENMSDVRE
LTPEFFYLPE FLTNCNAVEF GCMQDGTTLG DVQLPPWADG DPRKFISLHR QALESDFVSA
HLHHWIDLIF GYKQQGPAAV EAINTFHPYF YGDRVDLSSI SDPLIKSTIL GFVSNFGQVP
KQLFSKPHPA RTTTGKPSPG KDVSTPASLP SHSQSFLYSL QSLRPSQVTV KDMYLFSLGS
ESPKGAIGHI VPTEKTILAV EKNKVLLPPL WNRTFSWGFD DFSCCLGSYG SDKILMTFEN
LAAWGRCLCA ICPTSTMIVT SGASAVVCVW ELSMVKGHPR GLRLRQALYG HSQAVTCLAA
SVAFSLLVSG SQDATCILWD LDLLSYVARL PPHQEGISAI AISDISGTIV SCAGAHLSLW
NVNGQPLASI TTAWGPEGVI NCCCLMEGPA WDTNHVIITG SHDGIVRIWK TEDVKMSVPR
QTAAEETSVQ PPSPRGHKWE KNLALSRELD VSLALTGKPS KTSPAVTALA VSRNQTKLLV
GDEKGRIFCW SAEG
//
