ID   I3MFX9_ICTTR            Unreviewed;       508 AA.
AC   I3MFX9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Target of EGR1, exonuclease {ECO:0000313|Ensembl:ENSSTOP00000009580.3};
GN   Name=TOE1 {ECO:0000313|Ensembl:ENSSTOP00000009580.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009580.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000009580.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CAF1 family.
CC       {ECO:0000256|ARBA:ARBA00008372}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGTP01008728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005318027.1; XM_005317970.2.
DR   AlphaFoldDB; I3MFX9; -.
DR   STRING; 43179.ENSSTOP00000009580; -.
DR   Ensembl; ENSSTOT00000010672.3; ENSSTOP00000009580.3; ENSSTOG00000010669.3.
DR   GeneID; 101969255; -.
DR   CTD; 114034; -.
DR   eggNOG; KOG1990; Eukaryota.
DR   GeneTree; ENSGT00940000153167; -.
DR   HOGENOM; CLU_044804_1_0_1; -.
DR   InParanoid; I3MFX9; -.
DR   OrthoDB; 2879493at2759; -.
DR   TreeFam; TF314502; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0015030; C:Cajal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:Ensembl.
DR   GO; GO:0017069; F:snRNA binding; IEA:Ensembl.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IEA:Ensembl.
DR   Gene3D; 6.10.250.3220; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR   InterPro; IPR006941; RNase_CAF1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR   PANTHER; PTHR15092:SF37; TARGET OF EGR1 PROTEIN 1; 1.
DR   Pfam; PF04857; CAF1; 2.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT   DOMAIN          293..321
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         293..321
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          334..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  56705 MW;  ADB446EC75F28115 CRC64;
     MAADSDDGAA SAPAASDGCI NKCTKSGDEL IQVPVVDVQS DNFKEMWPSL LLAIKTASFV
     AVDTELSGLG DRKSLLNQCI EERYKAVCHA ARTRSILSLG LACFKLQPDK GEHSYLVQVF
     NLTLLCMEEY VIEPKSVQFL VQHGFNFNRQ YAQGIPYHKG NDKGDESQSQ SVRTLFLELI
     RARRPLVLHN GLIDLVFLYQ NFYAHLPESL GTFTADLCEM FPSGIYDTKY AAEFHARFTA
     SYLEYAFRKC ERENGKQRAG SNPHLTLEFC SYPSSMRAHI DYRCCMTPAI HRPHPTSICD
     NFSAYGWCPM GPQCPRSHDI DLIIDTDEAV IEDKRRRRRR REKRRRALLS LPGTQTSGEA
     EDGPPTKQVH GDLKAEEIEQ KVAEVDTKDQ PGSDQDHKND LEKELKATRY ETTDMATSEV
     PGGQASLNPV PGDGLHRAGF DAFMTGYVMA YVGVIQGPQS CSSEPWLPEC HNKVYLSGKA
     VPLTVAKSQF SRSSKAHNQK MKLAWGSS
//