ID I3MGN5_ICTTR Unreviewed; 649 AA.
AC I3MGN5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Galactosidase beta 1 like {ECO:0000313|Ensembl:ENSSTOP00000009948.3};
GN Name=GLB1L {ECO:0000313|Ensembl:ENSSTOP00000009948.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009948.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000009948.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01062693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005330554.1; XM_005330497.2.
DR AlphaFoldDB; I3MGN5; -.
DR STRING; 43179.ENSSTOP00000009948; -.
DR Ensembl; ENSSTOT00000011089.3; ENSSTOP00000009948.3; ENSSTOG00000011089.3.
DR GeneID; 101968147; -.
DR CTD; 79411; -.
DR eggNOG; KOG0496; Eukaryota.
DR GeneTree; ENSGT00950000182942; -.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; I3MGN5; -.
DR OrthoDB; 5489808at2759; -.
DR TreeFam; TF314816; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR PANTHER; PTHR23421:SF50; BETA-GALACTOSIDASE-1-LIKE PROTEIN; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..649
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011448704"
FT DOMAIN 38..353
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 400..512
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 537..594
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 185
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 263
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 649 AA; 73722 MW; 7D8E4CC871D23DE9 CRC64;
MAPEKPPCLP FLMLPLLTLL LQQADPRSFV VDRERGLFLL DGTPFRYVSG SLHYFRVPRI
LWADRLFKMR LSGLNAVQLY VPWNFHEPEP GVYNFNGSRD LFTFLNEAAI ANLLVILRPG
PYICAEWEMG GLPSWLLRNP KINLRTSDPD FLAAVDSWFK VLLPKIYPFL YHNGGNIISI
QVENEYGSYW ACDFNYMRHL AGLFRALLGD KILLFTTDGP DGLKCGTLKG LFATIDFGPA
DNMTRIFALL QKYEPHGPLV NSEYYTGWLD YWGQNHSTRS IEPIAKGLEN MLKLGASVNM
YMFHGGTNFG YWNGADEKGR FLPITTSYDY DAPISEAGDT TPKLFALRNV IGKFQEVPLG
PLPPPSHKMM LGPLTMHLDG DLLGFLDFLC PQGPIHSVMP LTFEAVKQDH GYMLYRTYLS
YSIFEPTPLW VPNNGVHDRA YVMMDGVIQG VLERNTDNKL YLMGKVGTKL DILLENMGRL
SFGSNHSDFK GLLEPPILGQ TILTQWMIFP LKVDHFVKWW YTFKLPKRPQ PKDPSGPTFY
STMFPILGSA GDTFLYLPGW TKGQVWINGF NLGRYWTKLG PQHTLYVPRP LLLPRGAVNT
ITLLELENVP LQPQIQFLDR PILNSTVHRI LSLSPDVQND TELMELSGH
//
