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Database: UniProt
Entry: I3MGP1_ICTTR
LinkDB: I3MGP1_ICTTR
Original site: I3MGP1_ICTTR 
ID   I3MGP1_ICTTR            Unreviewed;      1681 AA.
AC   I3MGP1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSSTOP00000009956};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009956, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000009956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000009956}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AGTP01000226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000009956; -.
DR   Ensembl; ENSSTOT00000011098; ENSSTOP00000009956; ENSSTOG00000011072.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3MGP1; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    114    135       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    141    164       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    236    259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    368    396       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    504    521       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    533    555       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    628    647       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    704    726       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    933    952       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    973    992       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    998   1015       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1058   1079       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1168   1193       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1242   1269       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1281   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1306   1330       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1368   1396       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1472   1498       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1512   1547       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      448    468       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1681 AA;  194047 MW;  892A503567C35620 CRC64;
     MLDSTEPKGL VPFTEESLKL IKQHIAKKHN EEHEEDDLKP DSALEVGKKL PFIYGELSRG
     MVSEPLEDVD SYYYVKKNTF MVLNKKRTIF RFNAASILCT LSPFSPIRGT TIKVLLTFFR
     LLILISVLTD CIFMTMTNWS IWITAIENTL LGIYTFEILV KIIARGFWAG SFSFLADPWN
     WLDFGVTLFE IITRYSPLNF VLNLKTVRTL RILKIIPLNQ GLKSLVETLI QCLKKLFGAI
     ILTLFFLSVF SLIGMGLFMG NLKHKCLRWP QEDENETLHN RTGNPYYIRE TENFYYLEGE
     RYALLCGNTT DAGQCPEGYV CVKAGLNPDL GYTNFDNFGW ALLALFRLMT QDYPEALYHQ
     ILYASGKIYM IFFVVVSFWF AFYLASLFLG ILAMAYEEGK HATDEKSKKE PTFQQPISKL
     QEGSEEAESK TTQIEMKKRS PASMNTSLDV LEEDTLRHKE ELKKSRKKCP LCWYRFSKFF
     LIWNCSPCWL KLKEFVHRLI TDPFTDLFLL ICIILNIYFL AWEHYPMSDD HSYLLSIGNL
     VFLGIFTAEM IFKIIAMNPY WYFQVGWNIF DSLIVLQGLA ELYLANIEGL ALCQSFRMLR
     VFKLGKYWPT FEILMLTLGN SLSALKDLIL LLFTFIFFSA VFGMKLFGWS YKACVCRIDE
     NCQLPRWHMH DFFHSCLNVF RILCGEWIET LWDCMEVAGQ PWCISFYMMV ILIGNLLVLY
     LFLALVSSFS SYKDSTSEEN NEVKNIQLAM ARIKKGVNYV LHKILCKKQN VPQETTDHVN
     DTYVKENISD HTLSEFSNTQ VFLKDKEKSS GTEKNTMTDN ESQSLIPSPS VSETVPIASG
     ESDVENLDNK EIQSKSGNGD SRDKIKQSSS SECSTVDIAI SEEEEMVYEC EKAKYLKNGF
     EQRSSPGQIS RVSKKAKIWQ NIRKTCCKIV ENSWFRCFIG LVTLLSTGAL AFEDIYIDQR
     KTIKILLEYA DMIFTYIFIL EMLLKWMAYG FKAYFSNGWY KLDFMVVIVF CLSLLGKTRE
     DLKPLTSIKF LRALRVLSQF ERMKVVVRGL IKTILPTLNV FLVCLMIWLI FSIMGVHLFS
     GTFYECIDPT SEERFPVSEV VNRSQCENLV LNESMPWENA KLNFDNVGNG FLSLLQVATF
     NGWITIMNSA IDSVGVNMQP DFEYNLYIYY YFISFIILGL FLPLSMLISV IITNFNKHKI
     KIRGSNIFIT VKQRKQYRKL KRLMYEDSPR PLPRPRNKFQ GFVFDLVTNQ VFNIIIMVLI
     HVQAVTIMIQ SDEQSQQMDI AVYWINAIFV ILYTLECILK LISFHCYYFT IIWNVFDFVV
     VIFSITGLFL PMTIGYYLVP PSLVQLILLS RIIHVLRLGK GPRVFHNLML PLMLSLPALL
     NIGLFIFLVM FIYAIFGMYN FAYVKKEAGI NDVSNFETFG SSMLCLFQVT IFAGWDGMLN
     AIFNSKWSDC DPDKINPGTQ VRGDCGNPSV GIFYFVSYIL ISWLVIVNMY IVVVMEFLSI
     VSKKKSRTLS EDDFRKFFQV WKRFDPDRTQ YIDSSQLSDF AAALDPPLFM AKPNKGQLIA
     MDLPMAVGDR IHCLDILLAF TKRVMGKDAR VEKLLSEVES GFVLANPFKI TYEPITTTLK
     RKQEAVSATI IQRAYKSYRL RQNDKNTSDI HIIDGDRDVQ ATKEGVYFDK AKEKSTIQSQ
     I
//
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