ID I3MGQ7_ICTTR Unreviewed; 428 AA.
AC I3MGQ7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Sphingosine-1-phosphate phosphatase 1 {ECO:0000313|Ensembl:ENSSTOP00000009979.3};
GN Name=SGPP1 {ECO:0000313|Ensembl:ENSSTOP00000009979.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009979.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000009979.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01026955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MGQ7; -.
DR STRING; 43179.ENSSTOP00000009979; -.
DR Ensembl; ENSSTOT00000011125.3; ENSSTOP00000009979.3; ENSSTOG00000011129.3.
DR eggNOG; KOG2822; Eukaryota.
DR GeneTree; ENSGT00940000158836; -.
DR HOGENOM; CLU_043042_1_0_1; -.
DR InParanoid; I3MGQ7; -.
DR TreeFam; TF323419; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042392; F:sphingosine-1-phosphate phosphatase activity; IEA:Ensembl.
DR GO; GO:0035621; P:ER to Golgi ceramide transport; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0097193; P:intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0006668; P:sphinganine-1-phosphate metabolic process; IEA:Ensembl.
DR GO; GO:0006670; P:sphingosine metabolic process; IEA:Ensembl.
DR CDD; cd03388; PAP2_SPPase1; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR PANTHER; PTHR14969:SF45; SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 1; 1.
DR PANTHER; PTHR14969; SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 148..262
FT /note="Phosphatidic acid phosphatase type 2/haloperoxidase"
FT /evidence="ECO:0000259|SMART:SM00014"
FT REGION 30..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 48044 MW; 4445B52741B1EEA2 CRC64;
MSLRQHLAQL AACLQEPQKV ARFQRLCGVE APPNRSADRR EDEKLEAPLA GDPRRRGRQS
GATEVKPDGS GAPNGVRNGL AAELGPTSSQ RAGSLRRNSL TGEEGELARL SNWPLYYLFC
FGTELGNELF YIMFFPFWIW NLDPLVGRRL VIIWVLVMYL GQCTKDIIRW PRPSSPPVVK
LEVFYNSEYS MPSTHAMSGT AIPIAMVLLT YGRWQYPPIY GLILIPCWCS LVCLSRIYMG
MHSILDIIAG FLYTILILAV FYPFVDLIDN FNQTHKYAPL IIIGLHLSLG IFSFTLDTWS
TSRGDTAEIL GSGAGIACGS HVAYSVGLLL DPSLEILPFT RPPITVTLFG KAILRILIGM
IFVLIVRDIM KKITIPLACK IFNIPCDDIR KARQHMEVEL PYRYITYGMV GFSITFLVPY
IFFFIGIS
//
