ID   I3MGU0_ICTTR            Unreviewed;      1078 AA.
AC   I3MGU0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Importin 5 {ECO:0000313|Ensembl:ENSSTOP00000010024.3};
GN   Name=IPO5 {ECO:0000313|Ensembl:ENSSTOP00000010024.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010024.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000010024.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AGTP01004457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01004458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3MGU0; -.
DR   STRING; 43179.ENSSTOP00000010024; -.
DR   Ensembl; ENSSTOT00000011176.3; ENSSTOP00000010024.3; ENSSTOG00000011164.3.
DR   eggNOG; KOG2171; Eukaryota.
DR   GeneTree; ENSGT00940000155502; -.
DR   HOGENOM; CLU_003794_0_1_1; -.
DR   InParanoid; I3MGU0; -.
DR   TreeFam; TF300344; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR   GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0006610; P:ribosomal protein import into nucleus; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR041653; Importin_rep_4.
DR   InterPro; IPR040928; Importin_rep_5.
DR   InterPro; IPR041389; Importin_rep_6.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF22; IMPORTIN-5; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF18808; Importin_rep_4; 1.
DR   Pfam; PF18816; Importin_rep_5; 1.
DR   Pfam; PF18829; Importin_rep_6; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          26..80
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   1078 AA;  121867 MW;  D4AE373A498BCE13 CRC64;
     FSAEYLKSFS TETYENIPGQ SKITFLLQAI RNTTAAEEAR QMAAVLLRRL LSSAFDEVYP
     TLPSDVQTAI KSELLMIIQM ETQSSMRKKI CDIAAELARN LIDEDGNNQW PEGLKFLFDS
     VSSQNMGLRE AALHIFWNFP GIFGNQQQHY LDVIKRMLVQ CMQDQEHPSI RTLSARATAA
     FILANEHNVA LFKHFADLLP GFLQAVNDSC YQNDDSVLKS LVEIADTVPK YLRPHLEATL
     QLSLKLCGDT SLNNMQRQLA LEVIVTLSET AAAMLRKHTN IVAQTIPQML AMMVDLEEDE
     DWANADELED DDFDSNAVAG ESALDRMACG LGGKLVLPMI KEHIMQMLQN PDWKYRHAGL
     MALSAIGEGC HQQMEGILNE IVNFVLLFLQ DPHPRVRYAA CNAVGQMATD FAPGFQKKFH
     EKVIAALLQT MEDQGNQRVQ AHAAAALINF TEDCPKSLLI PYLDNLVKHL HSIMVLKLQE
     LIQKGTKLVL EQVVTSIASV ADTAEEKFVP YYDLFMPSLK HIVENAVQKE LRLLRGKTIE
     CISLIGLAVG KEKFMQDASD VMQLLLKTQT DFNDMEDDDP QISYMISAWA RMCKILGKEF
     QQYLPVVMGP LMKTASIKPE VALLDTQDME NMSDDDGWEF VNLGDQQSFG IKTAGLEEKS
     TACQMLVCYA KELKEGFVEY TEQVVKLMVP LLKFYFHDDI LYSTAESMPL LLECARVRGP
     EYLTQMWHFM CDALIKAIGT EPDSDVLSEI MHSFAKCIEV MGDGCLNNEH FEELGGILKA
     KLEEHFKNQE LRQVKRQDED YDEQVEESLQ DEDDNDVYIL TKVSDILHSI FSSYKEKVLP
     WFEQFLPLIV NLICPHRPWP DRQWGLCIFD DVIEHCSPAS FKYAEYFLRP MLQYVCDNSP
     EVRQAAAYGL GVMAQYGGDN YRPFCTEALP LLVRVIQSAD SKTKENVNAT ENCISAVGKI
     MKYKPDCVNV EEVLPHWLSW LPLHEDKEEA VQTFNYLCDL IESNHPIVLG PNNTNLPKIF
     SIIAEGELHE AIKHEDPCAK RLANVVRQVQ TSGGLWTECI AQLSPEQQAA IQELLNSA
//