ID I3MGY6_ICTTR Unreviewed; 444 AA.
AC I3MGY6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Lipase H {ECO:0000313|Ensembl:ENSSTOP00000010089.3};
GN Name=LIPH {ECO:0000313|Ensembl:ENSSTOP00000010089.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010089.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000010089.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR EMBL; AGTP01065717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MGY6; -.
DR STRING; 43179.ENSSTOP00000010089; -.
DR ESTHER; icttr-i3mgy6; Phospholipase.
DR Ensembl; ENSSTOT00000011248.3; ENSSTOP00000010089.3; ENSSTOG00000011247.3.
DR eggNOG; ENOG502QUQT; Eukaryota.
DR GeneTree; ENSGT00940000156285; -.
DR HOGENOM; CLU_027171_3_0_1; -.
DR InParanoid; I3MGY6; -.
DR TreeFam; TF324997; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004620; F:phospholipase activity; IEA:Ensembl.
DR GO; GO:0016042; P:lipid catabolic process; IEA:Ensembl.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF12; LIPASE MEMBER H; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 32..319
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT ACT_SITE 148
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 172
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 242
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 186
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 188
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 191
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ SEQUENCE 444 AA; 50019 MW; 5F6C1A1A222C305A CRC64;
QERLCNFISA RSTETCPSFT RLSFHSAVVG TGLQVRLMLY TKRNQTCAQI INSTALGNLN
VTKKTTFIIH GFRPTGSAPV WMGDLVEALL SAEHMNVVVV DWNRGATTVI YTHAANKTKK
VAIILKEFID QMLAEGASLD NIYMIGVSLG AHISGFVGEM YDGQLGRITG LDPAGPLFNG
RPPQDRLDPS DAQFVDVIHS DTDALGYKEP LGNIDFYPNG GLDQPGCPQT IFGGIKYFKC
DHQRSVYLYL ASLREDCEIT AYPCDSYRDY RNGKCTSCGT PEQSCPVLGY YADNWKDYLK
QKDPPMTKAF FDTAEKEPFC MYHYFVDIIS WNKNIRRGSI TIKLRDRDGN TTESKIDHEP
ATFQKYHQVS LLARFNQDLD KVATISLVFS TGSVVGPKYK LRILRIRLRS LVHPERPQLC
RYDLVLMENV QTVFKPILCP KLQM
//
