ID I3MHN8_ICTTR Unreviewed; 2011 AA.
AC I3MHN8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN5A {ECO:0000313|Ensembl:ENSSTOP00000010423.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010423.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000010423.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AGTP01006791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000011614.3; ENSSTOP00000010423.3; ENSSTOG00000011601.3.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000161691; -.
DR HOGENOM; CLU_022231_0_0_1; -.
DR TreeFam; TF323985; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF206; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 381..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 711..729
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 741..762
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 774..791
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 831..854
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 874..891
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 911..934
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1199..1218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1239..1255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1267..1288
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1316..1342
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1438..1464
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1523..1541
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1553..1571
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1583..1603
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1640..1668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1743..1766
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 155..415
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 501..660
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 711..940
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 948..1194
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1198..1473
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1522..1776
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 27..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1950..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 406..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 473..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1063
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1952..1989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2011 AA; 227062 MW; 8F21E59A9C9ADA13 CRC64;
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSATSQ ESREGLPEEE APRPQLDLQA
SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV
RRAAVKILVH SYPLQLIPAV VDAVCTTWET WWDWYTFTAI YTFESLVKIL ARGFCLHAFT
FLRDPWNWLD FSVIVMAYTT EFVDLGNVSA LRTFRVLRAL KTISVISGLK TIVGALIQSV
KKLADVMVLT VFCLSVFALI GLQLFMGNLR HKCVRNFTEL NGTNGSVEAD GLVWDSLDLY
LNDPENYLIK NGTSDVLLCG NSSDAGTCPE GYRCLKAGEN PDHGYTSFDS FAWAFLALFR
LMTQDCWERL YQQTLRSAGK IYMIFFMLVI FLGSFYLVNL ILAVVAMAYE EQNQATIAET
EEKEKRFQEA MEMLKKEHEA LTIRGVDTVS RSSLEMSPLA PVTNHERRSK RRKRMSSGTE
ECGDDRFPKS DSEDGPRVMN RLSLTHGLSR TSVKPRSSRG SIFTFRRRDL GSETDFADDE
NSTAGDSESH RTSLLVPWPL RRPSAQGQPS PGAAAPGHVL NGKRNSTVDC NGVVSLLGAG
DPEATSPGSR LLRPMMLERP PDTTTPSEDP GGPQMLTPQA PCVDGFEEPG ARQRALSAVS
ILTSALEELE ESHRKCPPCW NRFAQRYLIW ECCPLWMSIK QKVKFVVMDP FADLTITMCI
VLNTLFMALE HYNMTTEFEE MLQVGNLVFT GIFTAEMTFK IIALDPYYYF QQGWNIFDSI
IVILSLMELG LSRMGNLSVL RSFRLLRVFK LAKSWPTLNT LIKIIGNSVG ALGNLTLVLA
IIVFIFAVVG MQLFGKNYSE LRHRISDSGL LPRWHMMDFF HAFLIIFRIL CGEWIETMWD
CMEVSGQSLC LLVFLLVMVI GNLVVLNLFL ALLLSSFSAD NLTAPDEDGE MNNLQLALAR
IQRGLRFVKR TTWDFCCGLL RRRPKKPAAL ASHGQLPSCI ANPSSPPPPE TDKAPPARKE
TRFEEDKRPG QGTPGDPEPV CVPIAVAESD TDDQDEDEEN SQGTEEESSK QESQPVSSGP
ESHPEPRAWS QVSETASSEA EASASQADWR QQQKAEPRSP GCSETHEDSY SEGSTADMTN
TADLLEQIPD LGEDVKDPED CFTEGCVRRC PCCAVDTTQA PGKVWWRLRK TCYRIVEHSW
FETFIIFMIL LSSGALAFED IYLEERKTIK VLLEYADKMF TYVFVLEMLL KWVAYGFKKY
FTNAWCWLDF LIVDVSLVSL VANTLGFAEM GPIKSLRTLR ALRPLRALSR FEGMRVVVNA
LVGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFGRCINQ TEGDLPLNYT IVNNKSECES
FNVTGELYWT KVKVNFDNVG AGYLALLQVA TFKGWMDIMY AAVDSRGYEE QPQWEYNLYM
YIYFVVFIIF GSFFTLNLFI GVIIDNFNQQ KKKIRGQDIF MTEEQKKYYN AMKKLGSKKP
QKPIPRPLNK YQGFIFDIVT KQAFDVTIMF LICLNMVTMM VETDDQSPEK VNILAKINLL
FVAIFTGECI VKMAALRHYY FTNSWNIFDF VVVILSIVGT VLSDIIQKYF FSPTLFRVIR
LARIGRILRL IRGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYSIFGM SSFAYVKWEA
GIDDMFNFQT FANSMLCLFQ ITTSAGWDGL LSPILNTGPP YCDPNLPNSN GSRGNCGSPA
VGILFFTTYI IISFLIVVNM YIAIILENFS VATEESTEPL SEDDFDMFYE IWEKFDPEAT
QFIEYSALSD FADALSEPLR IAKPNQISLI NMDLPMVSGD RIHCMDILFA FTKRVLGESG
EMDALKIQME EKFMAANPSK ISYEPITTTL RRKHEEVSAT VIQRAFRRHL LQRSVKHASF
LFRQRVGSSG LSEEDAPERE GLIAYMMNEN FSQRGGPPSS SSISSTSFPP SYDSVTRATS
DNLQLRVSDY SRSEDLADFP PSPDRDRESI V
//
