ID   I3MHV7_ICTTR            Unreviewed;       693 AA.
AC   I3MHV7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Hook microtubule tethering protein 2 {ECO:0000313|Ensembl:ENSSTOP00000010514.3};
GN   Name=HOOK2 {ECO:0000313|Ensembl:ENSSTOP00000010514.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010514.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000010514.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the hook family.
CC       {ECO:0000256|ARBA:ARBA00006946}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGTP01088432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3MHV7; -.
DR   Ensembl; ENSSTOT00000011718.3; ENSSTOP00000010514.3; ENSSTOG00000011709.3.
DR   GeneTree; ENSGT00940000160152; -.
DR   HOGENOM; CLU_011214_2_0_1; -.
DR   TreeFam; TF320231; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR   CDD; cd22227; HkD_Hook2; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR   PANTHER; PTHR18947:SF37; PROTEIN HOOK HOMOLOG 2; 1.
DR   Pfam; PF05622; HOOK; 2.
DR   Pfam; PF19047; HOOK_N; 1.
DR   SUPFAM; SSF116907; Hook domain; 1.
DR   PROSITE; PS50021; CH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          6..122
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   COILED          208..403
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          451..580
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   693 AA;  80339 MW;  B867E50DFA8C9F77 CRC64;
     MSVDKAELCG SLLTWLQTFQ VPPPCASPED LSSGLAVAHV LNQIDPSWFN ETWLQDISED
     PGPNWRLKVS NLQKILQSLV EYSQDVLGHP VSEQHLPDVS LIGEFSDPTE LGKLLQLVLG
     CAISCEKKQE HIQRIMTLEE SVQHIVMEAI QELMTKDTQE SLSQETYGNF DTQSRRYYFL
     SEDAEEGDEL RQHCLDLERQ LVLLSEVKQS LVQENASLRE RVGRSQAEVT PGVTAKKLLL
     LQSQLEQLQE ENFRLESSRE DERLRCAELQ REVTELQQRN QALTSLAQEA QALKDEMDEL
     RQSSERAGQL EECNAGHAER TRQLEEELRR AGSLRAQLEA QRRQVQELQS QRQEEAMKAE
     KWLFECRNLE EKYESVTKEK ERLLAERDSL REANEELRCA QLQPRGLTQA DPSLDPTPLG
     LENLAAEILP AELRETLLRL QLENKRLCQQ EAADRERQEE LQRHLEEANR ARHGLETQHR
     LNQQQLSELR AQVEDLQKAL QEQGGKTEDP TLLKRKLEEH LQKLREADLE LQRKREYLEE
     LETPSDNSTA RRIEELQDSL QKKDADLRAM EERYRRYVDK ARTVIQTLEP KQRPPGEGTP
     ELHTLRTQLR ERDVRIRHLE MDFEKNRSQR EQEEKLLISA WYNMGMALQQ RAGEERAPAH
     AQSFLAQQRL ATNGRRGPLG RLASLNLRPT DKH
//