ID I3MIP9_ICTTR Unreviewed; 1261 AA.
AC I3MIP9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN Name=NPHP3 {ECO:0000313|Ensembl:ENSSTOP00000010920.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010920.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000010920.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01046420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01046421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MIP9; -.
DR STRING; 43179.ENSSTOP00000010920; -.
DR Ensembl; ENSSTOT00000012179.3; ENSSTOP00000010920.3; ENSSTOG00000012174.3.
DR eggNOG; KOG1840; Eukaryota.
DR GeneTree; ENSGT00940000156398; -.
DR HOGENOM; CLU_007418_0_0_1; -.
DR InParanoid; I3MIP9; -.
DR TreeFam; TF314010; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0097543; C:ciliary inversin compartment; IEA:Ensembl.
DR GO; GO:0003283; P:atrial septum development; IEA:Ensembl.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0071908; P:determination of intestine left/right asymmetry; IEA:Ensembl.
DR GO; GO:0071910; P:determination of liver left/right asymmetry; IEA:Ensembl.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IEA:Ensembl.
DR GO; GO:0071909; P:determination of stomach left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060993; P:kidney morphogenesis; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0048496; P:maintenance of animal organ identity; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; IEA:Ensembl.
DR GO; GO:0072189; P:ureter development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 6.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 916..949
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1024..1057
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1066..1099
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1108..1141
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1150..1183
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1192..1225
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1227..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..134
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1065..1092
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1232..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 144417 MW; C49FD3372E9392C7 CRC64;
RYTHHDVAQW QSTSGSIPTA EYERLKKEYE IFRVSKNQEL LSMGRREAKL DTENKRLRAE
LQALQKTYQK ILREKESALE AKYQAMERAA TFEHDRDKVK RQFKIFRETK ENEIQDLLRA
KRELESKLQR LQAQGIQVFD PGESDSDDNC TDITAAGTQC EYWSGGALGS EPSIGSLIQL
QQSFRGPEFA HSSIDVEGPF ANVNRDDWDV AVASLLQVTP LFSHSLWSNT VRCYLMYTEE
TQPEMDLFLK DYSPKLKRMC ETMGYFFHAV YFPIDVENQY LTIRKWEIEK SSLVILFIHS
TLPSLLLEDC EEAFLKNPEG KPRLIYHRLE DGKVSSDSVQ LLIDQVSNLN KANKAKFIDH
SGDPAEGVYK TYICVEKIIK QDILGFENTD LETKDLGSDD SLPEEDDFGD VLWDIHDEQE
QMETFQQASN SAHELGFEKY YQRLNDLVAA PAPIPPLLVS GGPGSGKSLL LSKWIQLQQK
NSPNTLILSH FVGRPMSTSS ESSLIIKRLT LKLMQHSWSV SALTLDPAKL LEEFPRWLEK
LSARHQGSII IVIDSIDQVQ QVEKHMKWLI DPLPVNVRVI VSVNVETCPA AWRLWPTLHL
DPLNPKDAKS IIIAECHSVD IKLSKEQEKK LERHCRSATT CNALYITLFG KMMARAGRAG
GVDKILHECL QCQDTVSLYR LVLRSIKESM TDDTDKELMR QILCLVNVSH NGVSESELME
LYPEMSWAVL TSLIHSLHKM CLLTYGCGLL RFQHLQAWET VRLEYMDGPA TISSYRQKLI
SFFTSQLSQD RVTWRIADEL PWLLQQQGSK QKLHGCLLNL FVSQNLYKRG HFAELLSYWQ
YVGKDKSAMA TEYFDSLKQY EKNCEGEENM ICLADLYETL GRFLKDLGLL SQAVVPLQRS
LEIRETALDP DHPRVAQSLH QLASVYVQWK KFGNAEQLYK QALEISENAY GADHPHTARE
LEALATLYQK QNKYEQAEHF RKKSFKIRQK ATRRKGNLYG FALLRRRALQ LEELTLGKDT
PDNARTLNEL GVLYYLQNNL ETADQFLKRS LEMRERVLGP DHPDCAQSLN NLAALCNEKK
QYEKAEELYE RALDIRKRAL APDHPSLAYT VKHLAILYKK TGKLDKAVPL YELAVEIRQK
SFGPKHPSVA TALVNLAVLY CQMKKHIEAL PLYERALKIY EDSLGRMHPR VGETLKNLAV
LSYEEGDFEK AAELYKRAME IKEAETSLLG GKAPSRHSSS GDTFSLKTTH SPNVFLPRGQ
R
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