ID I3MIX3_ICTTR Unreviewed; 231 AA.
AC I3MIX3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Interleukin 22 receptor subunit alpha 2 {ECO:0000313|Ensembl:ENSSTOP00000011032.2};
GN Name=IL22RA2 {ECO:0000313|Ensembl:ENSSTOP00000011032.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011032.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011032.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01059527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005329881.1; XM_005329824.1.
DR AlphaFoldDB; I3MIX3; -.
DR STRING; 43179.ENSSTOP00000011032; -.
DR Ensembl; ENSSTOT00000012312.2; ENSSTOP00000011032.2; ENSSTOG00000012313.2.
DR GeneID; 101976834; -.
DR CTD; 116379; -.
DR eggNOG; ENOG502S2NT; Eukaryota.
DR GeneTree; ENSGT00940000161124; -.
DR HOGENOM; CLU_081158_1_0_1; -.
DR InParanoid; I3MIX3; -.
DR OMA; SMENYYE; -.
DR OrthoDB; 5307423at2759; -.
DR TreeFam; TF332537; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042017; F:interleukin-22 binding; IEA:Ensembl.
DR GO; GO:0042018; F:interleukin-22 receptor activity; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF51; INTERLEUKIN-22 RECEPTOR SUBUNIT ALPHA-2; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..231
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003676834"
FT DOMAIN 8..114
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 127..230
FT /note="Interferon/interleukin receptor"
FT /evidence="ECO:0000259|Pfam:PF09294"
SQ SEQUENCE 231 AA; 26871 MW; DDFF6CD7AA681CE1 CRC64;
MRRKHCFLGV LVSLLLTGGE GILPAHDSLK PQKVQFQSRN FQNILHWQRG KALTGNNSTY
FVQYKMYGQR QWQNKEDCWG TPELFCDLTN ETSNLQEPYY ARVRMASAGR YSDWSLSPRF
FPWWEMKIDP PVVNITQING SSWVVLHAPH LPYKEQKGKN ISMENYYNLL YRVFIIKTSL
KKEQQVYEGT NGVAEIEALT PHSGYCVVAE IYLPLLDRRS QRSKERCVGT P
//
