ID I3MJ00_ICTTR Unreviewed; 833 AA.
AC I3MJ00;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Leucine rich repeats and guanylate kinase domain containing {ECO:0000313|Ensembl:ENSSTOP00000011072.3};
GN Name=LRGUK {ECO:0000313|Ensembl:ENSSTOP00000011072.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011072.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011072.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01065932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01065933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01065934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005331186.1; XM_005331129.1.
DR AlphaFoldDB; I3MJ00; -.
DR STRING; 43179.ENSSTOP00000011072; -.
DR Ensembl; ENSSTOT00000012354.3; ENSSTOP00000011072.3; ENSSTOG00000012348.3.
DR GeneID; 101963825; -.
DR CTD; 136332; -.
DR eggNOG; KOG0531; Eukaryota.
DR eggNOG; KOG0707; Eukaryota.
DR GeneTree; ENSGT00940000157992; -.
DR HOGENOM; CLU_019293_0_0_1; -.
DR InParanoid; I3MJ00; -.
DR OrthoDB; 1331402at2759; -.
DR TreeFam; TF329158; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 417..600
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..99
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 94123 MW; 5494742A5072B5E2 CRC64;
MAASEGGPQG PRAPSLQRAF NSLRTGSPSV MLHSEKERYP CWSSFPMGQK QKSTFSKDSS
YLLQQLIHRY QESEAEGEDY QGEPEGEGES EESSESEMLN LEEEFDGVLR EEAVAKALHE
LGRSGPGTEQ VYLNLTLSGC DLIDISILCG YVHLQKLDIS ANKIGDLSCV SCMPYLLELN
ASQNKLTSFF NFKPPKNLKM VDFSSNQISE MCNLSAYHAL TKLILDNNEI EEIRGLDMCS
SLTHLSLSNN RIMTISGLNS LPIKILCLSN NCIETITGLE NLKALQNLDL SHNQICSLQG
LENHDLLEVI NLEDNKIAEL NEIEYIENLP ILRILNLLRN PIQENPDYWL FVIFMLLRLT
ELDQKKIKVE EKVSAVNKYD PPPEVVAAQD HLTHVVNSVL QPQRIFDSTL PSLDAPYPML
ILAGPQACGK RELAHRLCRQ FSTYFRYGAC HTTRPPYFGE GDRVDYHFIS QEVFDEMLNM
GKFILTFNYG NHNYGLNRDT VEGIARDGLA SCIHMEIEGV RSLKYSYFEP RYILVVPMNK
EKYEGHLRRK GLFSRAEIEF AVSRVDLYIK INQNFPGYFD AVINADDLEV AYQRLSELIR
EYLGLTAEPA TSLAPTADVQ TSHLESEDAP RKSTASNIFD FRDPTDRNYF AKLWAKLSAR
KTPVERDSVH RQHEAARQAL MGKTPPGHTL LFQRGSVPAP AINGLQYFNG LQYFTALEDL
HKSFELSEDY FKFPFGPYAE KSGKTTYSKK YSALHSYLWS KEWSFQPPEG SISSRPGSGT
SDGEMDQALK ALHKQSSSFD KRTFQPKRHS GTVTVRPGSN TKPVLPPIPQ GYK
//
