ID I3MJP8_ICTTR Unreviewed; 321 AA.
AC I3MJP8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 08-NOV-2023, entry version 53.
DE SubName: Full=Myeloid associated differentiation marker {ECO:0000313|Ensembl:ENSSTOP00000011408.1};
GN Name=MYADM {ECO:0000313|Ensembl:ENSSTOP00000011408.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011408.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000256|ARBA:ARBA00034721}.
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DR EMBL; AGTP01120678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005342312.1; XM_005342255.1.
DR RefSeq; XP_005342313.1; XM_005342256.2.
DR RefSeq; XP_013221625.1; XM_013366171.1.
DR AlphaFoldDB; I3MJP8; -.
DR STRING; 43179.ENSSTOP00000011408; -.
DR Ensembl; ENSSTOT00000012731.2; ENSSTOP00000011408.1; ENSSTOG00000012737.2.
DR GeneID; 101963988; -.
DR CTD; 91663; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00950000182933; -.
DR HOGENOM; CLU_068368_0_0_1; -.
DR InParanoid; I3MJP8; -.
DR OMA; GGMADWC; -.
DR OrthoDB; 3818412at2759; -.
DR TreeFam; TF331088; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0061028; P:establishment of endothelial barrier; IEA:Ensembl.
DR GO; GO:0031579; P:membrane raft organization; IEA:Ensembl.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090038; P:negative regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0044860; P:protein localization to plasma membrane raft; IEA:Ensembl.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR047123; MYADM-like.
DR PANTHER; PTHR17068:SF3; MYELOID-ASSOCIATED DIFFERENTIATION MARKER; 1.
DR PANTHER; PTHR17068; MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER; 1.
DR Pfam; PF01284; MARVEL; 2.
DR PROSITE; PS51225; MARVEL; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..162
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 167..318
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
SQ SEQUENCE 321 AA; 35092 MW; CAE205072B2A9F7F CRC64;
MAVTVTRTTI TTTTTSSGLG SSTIVGSPRA LTQPLGLLRL LQLLSTCVAF SLVASVGAWM
GPMGNWSMFT WCFCFSVTLI ILIVELGGLQ ARFPLSWRNF PITYACYAAL FCLSSSIIYP
TTYVQFLSHG RTRDHAIAAT AFSCIACVAY ATEVAWTRAR PGEITGYMAT VPGLLKVLET
FVACIIFAFI SNPSLYQQKP ALEWCVAVYA ICFILAAIAI LLNLGDCTNM LPIPFPSFLS
GLALLSVILY ATALVLWPLY QFDERYGGRS QRARDGACAV RHPHFVCDWD RRLAVAILTA
INLLAYVADL VYSARLVFVK V
//