ID I3MKX1_ICTTR Unreviewed; 586 AA.
AC I3MKX1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Ankyrin repeat and SOCS box containing 14 {ECO:0000313|Ensembl:ENSSTOP00000011998.3};
GN Name=ASB14 {ECO:0000313|Ensembl:ENSSTOP00000011998.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011998.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011998.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; AGTP01005810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013217193.1; XM_013361739.1.
DR AlphaFoldDB; I3MKX1; -.
DR STRING; 43179.ENSSTOP00000011998; -.
DR Ensembl; ENSSTOT00000013391.3; ENSSTOP00000011998.3; ENSSTOG00000013391.3.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000156550; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; I3MKX1; -.
DR OrthoDB; 5479200at2759; -.
DR TreeFam; TF315127; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03730; SOCS_ASB14; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT REPEAT 115..147
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 148..180
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 181..213
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 214..246
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 247..279
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 312..344
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 354..386
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 384..416
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 528..575
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 586 AA; 65499 MW; D4BAFDB8CB7B5DE8 CRC64;
MDNYISDEDT DNDFDTQLTI QQSLQDIYKP RTTQHAPDES FHSFLSAYYK KIIETIETGE
EDALSHLTKY HSAFDEADEI GWTPLHKAAV QLNKNILEIT LKASKTSVWE QTTHNGETPL
FLAVSNCLLE NASFLLLNGC NPNAKNFEGN SPLLTAVLRD SYDMATLLIS HGADVNLRCA
NDRTVLHEAA KLGRQDMVKL MLVSGAHPDP RSTYGFTPLA LAAQSGHTEI MALLLQKGAN
AHGQASDSSS ILLEAARGGN PDSVTLLLEY GADANIPKIS GHLPIHVAAD RGHLLALKIL
IPVTDLAAIK RSGISPVHCA AAGAHPQCLE LLIQAGFDVN FMLDQKIRKH YDDQRKSALY
FAVSNGDLSS VKLLLGAGAL TNQDPVNCLQ IALRMGNYEL ISLLLRHGAN VNYFCRVNPL
HFPSALQYTL KDEVMLRMLL NYGYDTERCF DCPHGDKIHP FYTFEGWTST VIKDTMFCEV
ITLSWLQHLS GKVVRVMLDY VDQVQICSKL KAVLQKQGLW SEIHFILTNP RSLKHLCRLK
IRKCMGRLHL RCPVFMSFLP LPNRLKAYIL YKEYDLYGQG VFTETW
//
