ID I3MKX7_ICTTR Unreviewed; 780 AA.
AC I3MKX7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Cyclin-F {ECO:0000256|ARBA:ARBA00019493};
GN Name=CCNF {ECO:0000313|Ensembl:ENSSTOP00000012005.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012005.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000012005.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000256|ARBA:ARBA00006955}.
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DR EMBL; AGTP01095344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005337847.1; XM_005337790.2.
DR AlphaFoldDB; I3MKX7; -.
DR STRING; 43179.ENSSTOP00000012005; -.
DR Ensembl; ENSSTOT00000013398.3; ENSSTOP00000012005.3; ENSSTOG00000013396.3.
DR GeneID; 101963946; -.
DR CTD; 899; -.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00810000125541; -.
DR HOGENOM; CLU_020348_0_0_1; -.
DR InParanoid; I3MKX7; -.
DR OrthoDB; 3020936at2759; -.
DR TreeFam; TF101006; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0010826; P:negative regulation of centrosome duplication; IEA:Ensembl.
DR GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd20521; CYCLIN_CCNF_rpt1; 1.
DR CDD; cd20522; CYCLIN_CCNF_rpt2; 1.
DR CDD; cd22082; F-box_FBXO1; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10177:SF496; CYCLIN-F; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS00292; CYCLINS; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 29..76
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 564..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 86947 MW; 0CF2EA33D51C4627 CRC64;
MGSGGVIHCR CAKCFCYPTK RRIRRRPQNL TILNLPEDVL FHILKWLSVG DILAVRAVHS
HLKYLVDNHA SVWACASFQE LWPSPKNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD
EARAEVNGLK ASRFFSLAER LNVSAMPFIW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR
THRASILHCL GRVLNLFEDE EKKKQARHLF EESAHQGCLA SSYLLWESDR RMDMSDPGRC
LHSFRKLRDY AAKGCWEAQL ALAKACANGS QLGLEAKTCS EIVSQLFQAS QAISKQQVFS
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLAVECVDR YLRRRLVPRY KLQLLGIACM
VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIIST LEGKIRIPTV VDYKEVLLTL
VPVAPRTQHL CSFLCELSLL HTSLSAFAPA CLASAALLLA RLMHRQTQPW TSQLCDLTGF
SFEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYEEVSQEEV LSHSQLCVAL
GVKQESPEPP SFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGVLDVTV VYLNPEQHCC QESSDEETCQ
EDKGHQVPGT QTPPALGPRP LLHSRRGPGK DVTTSGYSSV SSASPTNSVD SGSGGPPLST
SVLSLGSNSD TQPCQHQAKK SCLQCRPPTP PGSSAPQQQV KRQNLSMHSG KDVNLGFLKL
//
