ID I3MLD7_ICTTR Unreviewed; 802 AA.
AC I3MLD7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Transferrin receptor 2 {ECO:0000313|Ensembl:ENSSTOP00000012218.2};
GN Name=TFR2 {ECO:0000313|Ensembl:ENSSTOP00000012218.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012218.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000012218.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AGTP01053229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005328523.1; XM_005328466.1.
DR AlphaFoldDB; I3MLD7; -.
DR STRING; 43179.ENSSTOP00000012218; -.
DR MEROPS; M28.973; -.
DR Ensembl; ENSSTOT00000013636.3; ENSSTOP00000012218.2; ENSSTOG00000013621.3.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_5_0_1; -.
DR InParanoid; I3MLD7; -.
DR OMA; QVVFNNH; -.
DR OrthoDB; 2428249at2759; -.
DR TreeFam; TF312981; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
DR GO; GO:0004998; F:transferrin receptor activity; IEA:Ensembl.
DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl.
DR GO; GO:0140298; P:endocytic iron import into cell; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl.
DR GO; GO:1903319; P:positive regulation of protein maturation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IEA:Ensembl.
DR GO; GO:0033572; P:transferrin transport; IEA:Ensembl.
DR CDD; cd09848; M28_TfR; 1.
DR CDD; cd02128; PA_TfR; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR InterPro; IPR037324; TfR1/2_PA.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR PANTHER; PTHR10404:SF33; TRANSFERRIN RECEPTOR PROTEIN 2; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..305
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 412..615
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 88658 MW; 30941F62376DFFE4 CRC64;
MERLRGLLQR AQQLSPQRSQ TIYKRVESPH QGRLEEEEED REEGAELPVH FCPMELRGPE
SPGSRAGLPN LIPWAAAGRR AAPYLVLTAL LIFTGAFLLG YVAFRRSCQA CGDSLLVVSE
DGNYELGLDS HQGTLYWSDL QAMFLRLLGE GRLEDTIRET SLRQRVAGSP GMAALAQDVV
AALSRQKLDH VWTDTHYVGL QFPDRAHPNT LRWLDETGRA GEQLPLEDPD AYCPYSATGN
ATGKLVYAHY GRPEDLQGLR ARGVELTDSL LLVRVGVTSF AQKVASAQDF GAKGVLIYPD
PADFSQDPHK PSLSSHRAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVASSG LPSIPAQPIS
ADIAFRLLRK LKGPVAPQEW QGRLPGSPYR LGPGPGLHLE VNNHRTSTPI SNIFGCIEGL
AEPDHYVVIG AQRDAWGPGA AKSAVGTGIL LELVRTFSSM VSNGFRPRRS LLFISWDGGD
FGSVGSTEWL EGYLSVLHLK AVAYVSLDNA VLGDDKFHAK TSPLLISLIE NILKQVDSPN
HSGQTLYEQV VFTNPSWDAE VIRPLPMDSS AYSFTAFAGV PAVEFSFLED DPAYPFLHTK
EDTYENLHKM LQGRLPAVAQ AVAQLAGQLL IRLSHDHLLP FDFGRYGDVV LRHIGSLNEF
SGDLKARGLT LQWVYSARGD YIRAAEKLRK EIYSSEERDE RLMRMYNVRI MRVEYYLLSQ
YVSPADFPFR HIFLGHGDHT LGALLDHLQL LRSNSSGASP KLSQALGFQE SRFRRQLALL
TWTLQGAANA LGGDVWNIDN NF
//
